Mitochondrial complex I and NAD(P)H oxidase are major s ...
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Mitochondrial complex I and NAD ...
We tested the hypothesis that pressure overload exacerbates oxidative stress associated with augmented mitochondrial permeability transition (MPT) p ...
660.15 KB
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Left ventricular dilation in to ...
Restoration of myocardial blood flow after ischemia triggers an inflammatory response involving tolllike receptors (TLRs). TLR2-/--mice show short-t ...
806.16 KB
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Distinct mechanisms for diastol ...
Chronic pressure-overload and diabetes mellitus are two frequent disorders affecting the heart. We aimed to characterize myocardial structural and f ...
692.27 KB
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Chronic cardiac pressure overlo ...
Increased activity of the sympathetic system is an important feature contributing to the pathogenesis and progression of chronic heart failure. Whil ...
945.71 KB
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Ischemia/reperfusion injury is ...
We hypothesized that nandrolone (ND)-abuse induces cardiac hypertrophy, increases myocardial susceptibility to ischemia/reperfusion (I/R) injury, an ...
دانلود 1
612.50 KB
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Central TNF inhibition results ...
This study examined the effect of central tumor necrosis factor-alpha (TNF) blockade on the imbalance between nitric oxide and superoxide production ...
1.04 MB
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The TIR/BB-loop mimetic AS-1 pr ...
Activation of NF-jB contributes to cardiac hypertrophy and the interleukin-1 receptor (IL-1R)-mediated MyD88-dependent signaling pathway predominate ...
750.78 KB
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Functional role of TASK-1 in th ...
TASK-1, a member of the recently identified K2P channel family, is mainly expressed in the heart and the nervous system. TASK-1 is regulated by seve ...
دانلود 2
604.16 KB
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EGFR trans-activation by uroten ...
Urotensin II (UTII) and its seven trans-membrane receptor (UTR) are up-regulated in the heart under pathological conditions. Previous in vitro studi ...
858.89 KB
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Mitochondria to nucleus translo ...
Heat shock protein 70 (Hsp70) has been shown to have an anti-apoptotic function, but its mechanism is not clear in heart. In this study, we examined ...
711.72 KB
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Diastolic dysfunction and arrhy ...
Transgenic (TG) Ca2?/calmodulin-dependent protein kinase II (CaMKII) dC mice develop systolic heart failure (HF). CaMKII regulates intracellular Ca2 ...
500.79 KB
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Glycogen synthase kinase 3 beta ...
The role of glycogen synthase kinase 3 beta (GSK-3b) in modulating Notch control of vascular smooth muscle cell (vSMC) growth (proliferation and apo ...
795.46 KB
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Discrepant electrophysiological ...
The left atrial (LA) posterior wall has been demonstrated to have regional electrophysiological differences with a higher arrhythmogenic potential l ...
882.44 KB
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Antiproliferative effect of est ...
The mitochondrial antioxidant enzyme manganese superoxide dismutase (MnSOD) and the zinc finger transcription factor Kruppel-like factor-4 (KLF4) ar ...
778.69 KB
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Evidence for an intracellular l ...
Protection achieved by ischemic preconditioning is dependent on A2B adenosine receptors (A2BAR) in rabbit and mouse hearts and, predictably, an A2BA ...
694.90 KB
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Conserved expression and functi ...
PDE4 isoenzymes are critical in the control of cAMP signaling in rodent cardiac myocytes. Ablation of PDE4 affects multiple key players in excitatio ...
646.76 KB
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OxLDL and macrophage survival: ...
Atherosclerotic plaques are characterized by hypoxic even anoxic areas and by high concentrations of oxidized lipoproteins. Moreover, unstable plaqu ...
577.91 KB
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Arterial flow reduces oxidative ...
The main sources of oxidative stress in the vessel wall are nicotine adenine dinucleotide phosphate (NADPH) oxidase (Nox) complexes. The endothelium ...
614.34 KB
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Cardiac-specific overexpression ...
Cardiomyocyte death is a major event of myocardial infarction. Previously, we and others have shown that E3 ligase-mediated protein turnover plays a ...
849.65 KB
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EH-myomesin splice isoform is a ...
The M-band is the prominent cytoskeletal structure that cross-links the myosin and titin filaments in the middle of the sarcomere. To investigate M- ...
1.25 MB
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Necrotic cell death in atherosc ...
Necrosis is a type of cell death characterized by a gain in cell volume, swelling of organelles, rupture of the plasma membrane and subsequent loss ...
644.62 KB
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Regulation of vascular guanylyl ...
In isolated cells, soluble guanylyl cyclase (sGC) activity is regulated by exogenous nitric oxide (NO) via downregulation of expression and posttran ...
450.63 KB
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Altered circadian rhythm of car ...
Circadian rhythms influence the incidence of adverse cardiac events but the underlying mechanisms are not well defined. We sought to investigate the ...
1.96 MB
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STAT3a interacts with nuclear G ...
Activation of the Janus Kinase 2/Signal Transducer and Activator of Transcription 3 (JAK2/ STAT3) pathway is known to play a key role in cardiogenes ...
746.25 KB
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Oncostatin M-enhanced vascular ...
The pleiotropic cytokine oncostatinM(OSM), a member of the glycoprotein (gp)130 ligand family, plays a key role in inflammation and cardiovascular d ...
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