Long-term open-label response t ...
A three-year open-label study of atomoxetine in adults with ADHD followed two multicenter, double-blind trials. In the double-blind trials, female g ...
Mothers of children with attent ...
This study focuses on mothers of children diagnosed with attention deficit/hyperactivity disorder (ADHD) and sets out (1) to characterize dimensions ...
Olfactory and gustatory sensiti ...
Recently, research on olfactory functions in attention-deficit/hyperactivity disorder (ADHD) has become prominent, whereas gustation has never been ...
Antecedents of ADHD: a historic ...
The concept of ADHD has evolved gradually and still carries some traces of its origins. The idea of uncontrolled behaviour as a medical problem aros ...
Globular glial tauopathies (GGT ...
A number of recent studies have described cases with tau-positive globular oligodendroglial inclusions (GOIs) and such cases have overlapping pathol ...
Peroxisomal alterations in Alzh ...
In Alzheimer’s disease (AD), lipid alterations are present early during disease progression. As some of these alterations point towards a peroxisoma ...
Macrophage migration inhibitory ...
Macrophage migration inhibitory factor (MIF), which inhibits apoptosis and promotes angiogenesis, is expressed in cancers suppressing immune surveil ...
Vasculitis-like neuropathy in a ...
Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease with variable involvement of other systems. A pathogenetic role of immune-mediat ...
Enhancement of endogenous neuro ...
Cerebral ischemia stimulates endogenous neurogenesis. However, the functional relevance of this phenomenon remains unclear because of poor survival ...
Postsynaptic degeneration as re ...
Impairment of synaptic plasticity underlies memory dysfunction inAlzheimer’s disease (AD). Molecules involved in this plasticity such as PSD-95, a m ...
Widespread non-central nervous ...
Fragile X-associated tremor/ataxia syndrome (FXTAS) is an adult-onset neurodegenerative disorder generally presenting with intention tremor and gait ...
The cerebellar component of Fri ...
Lack of frataxin in Friedreich’s ataxia (FRDA) causes a complex neurological and pathological phenotype. Progressive atrophy of the dentate nucleus ...
Factors affecting Ab plasma lev ...
Previous studies of Ab plasma as a biomarker for Alzheimer’s disease (AD) obtained conflicting results. We here included 715 subjects with baseline ...
The spinal muscular atrophy mou ...
Spinal muscular atrophy (SMA) is a neurodegenerative disease resulting from decreased levels of survival motor neuron 1 (SMN1) protein. Reduced SMN1 ...
Cholinergic imbalance in the mu ...
Hippocampal pathology was shown to be extensive in multiple sclerosis (MS) and is associated with memory impairment. In this post-mortem study, we ...
Cell stress induces TDP-43 path ...
TDP-43 has been implicated in the pathogenesis of amyotrophic lateral sclerosis and other neurodegenerative diseases. Here we demonstrate, using ne ...
Spindle cell oncocytoma of the ...
Spindle cell oncocytoma (SCO) is a rare, nonadenomatous tumor originating from the anterior pituitary gland. Composed of fusiform, mitochondrion-ric ...
SOCS3 promoter methylation is m ...
The suppressor of cytokine signaling 3 (SOCS3) gene is one of eight structurally related genes of the SOCS family and has been suggested to function ...
The most common type of FTLD-FU ...
rontotemporal lobar degeneration (FTLD) is clinically, pathologically and genetically heterogeneous. Recent descriptions of a pathological sub-type ...
A distinct region of the MGMT C ...
O6-Methylguanine-DNA methyltransferase (MGMT) is a DNA repair protein that removes alkyl DNA adducts such as those induced by alkylating agents. Los ...
Analysis of BRAF V600E mutation ...
Missense mutations of the V600E type constitute the vast majority of tumor-associated somatic alterations in the v-RAF murine sarcoma viral oncogene ...
Pediatric and adult sonic hedge ...
Recent integrative genomic approaches have defined molecular subgroups of medulloblastoma that are genetically and clinically distinct. Sonic hedgeh ...
Pathological heterogeneity in a ...
Mutations in the gene encoding the fused in sarcoma (FUS) protein are responsible for*3% of familial amyotrophic lateral sclerosis (ALS) and\1% of s ...
A new phenotype of mitochondria ...
Axial myopathy is a rare neuromuscular disease that is characterized by paraspinal muscle atrophy and abnormal posture, most notably camptocormia (a ...
Granular expression of prolyl-p ...
Alzheimer’s disease (AD) manifests with progressive memory loss and decline of spatial awareness and motor skills. Neurofibrillary tangles (NFTs) re ...