Potent CYP2D6 Inhibiting drugs do not increase relapse ...
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Potent CYP2D6 Inhibiting drugs ...
Endoxifen, the most active metabolite of the prodrug tamoxifen, is produced by cytochrome P450 CYP2D6. Breast cancer patients treated with tamoxifen ...
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Periodontal disease may associa ...
The main purpose was to evaluate the association between periodontal disease and the incidence of breast cancer in a prospective study of 3273 rando ...
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Defining breast cancer prognosi ...
The objective of this study is to define the survival outcomes associated with distinct molecular phenotypes defined by immunohistochemical staining ...
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A BRCA2 mutation incorrectly ma ...
Inherited mutations in the tumor suppressor genes BRCA1 and BRCA2 predispose carriers to breast and ovarian cancer. The authors have identified a mu ...
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Lack of an association between ...
Several studies have investigated the associations between AURKA T91A polymorphism and the susceptibility to breast cancer, but the results have bee ...
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Randomized phase III trial of a ...
Adjuvant cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) have proven highly effective in rapidly proliferating breast cancer (RPBC). It has ...
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Variation in genes coding for A ...
AMP-activated protein kinase (AMPK) is an energy sensing/signalling intracellular protein which is activated by an increase in the cellular AMP:ATP ...
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Role of ethnic variations in TN ...
TNF-a and -b, the multi-functional pro-inflammatory cytokines, are known to play important roles in both tumor progression and destruction based on ...
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Possible risk modifications in ...
Manganese superoxide dismutase (MnSOD) has been identified as an important scavenger of reactive oxygen species (ROS), which can cause oxidative str ...
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Germline mutations in BRCA1 and ...
Three mutations in BRCA1 (185delAG, 5382InsC) and BRCA2 (6174delT) predominate among high risk breast ovarian cancer Ashkenazi Jewish families, with ...
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Association between polymorphis ...
Trinucleotide repeat containing 9 (TNRC9) is a gene located at chromosome 16q12. Although of an uncertain function, it is a newly described risk fac ...
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No evidence of excess breast ca ...
This analysis addresses risk of breast cancer among women in BRCA-positive families who test negative for the family mutation. We compared the numbe ...
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Association between patient rep ...
Neurotoxicity is a common side-effect during taxane therapy. The prevalence and severity of long-term neurotoxicity following therapy is unknown. Th ...
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CAG repeat length polymorphism ...
We analyzed the length of the CAG repeats of the androgen receptor gene in Indian women with breast cancer, and compared the data with that of other ...
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Increased risk of contralateral ...
Breast cancer (BC) survivors are at increased risk of second cancers. Obesity is commonly recognized as a risk factor of BC in postmenopausal period ...
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VEGF 936C>T polymorphism and ...
Vascular endothelial growth factor (VEGF) is one of the most potent endothelial cell mitogens and plays an important role in angiogenesis. Many publ ...
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Effects of breast cancer surger ...
We examined the impact of surgical treatments (breast-conserving surgery [BCS], mastectomy alone, mastectomy with reconstruction) and surgical side- ...
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Preventable breast cancer is po ...
Breast cancer incidence has markedly increased in Western countries for reasons that are not entirely understood. We characterized periodic and age- ...
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Ixabepilone plus capecitabine i ...
Patients with metastatic breast cancer (MBC) previously treated with anthracyclines and taxanes often have decreased performance status secondary to ...
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Economic evaluation of the 21-g ...
The 21-gene signature is validated as a good predictor of recurrence for lymph node-negative/positive, hormone receptor-positive, early-stage breast ...
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A combined analysis of genome-w ...
In an attempt to identify common disease susceptibility alleles for breast cancer, we performed a combined analysis of three genome-wide association ...
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A functional 277T>C polymorp ...
X-ray repair cross-complementing 1 (XRCC1) plays a critical role in base excision repair and genetic variations of XRCC1 may be associated with canc ...
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Asian ethnicity and breast canc ...
The distribution of breast cancer molecular subtypes has been shown to vary by race/ethnicity, highlighting the importance of host factors in breast ...
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Genetic variants in COX-2, non- ...
Chronic inflammation has been consistently associated with cancers of several sites, including the breast, and inhibition of inflammation through th ...
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RAD51 G135C polymorphism is ass ...
Several studies have investigated the associations between RAD51 G135C polymorphism and the susceptibility to breast cancer, but results have been ...
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