KX-01, a novel Src kinase inhibitor directed toward the ...
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KX-01, a novel Src kinase inhib ...
KX-01 is the first clinical Src inhibitor of the novel peptidomimetic class that targets the peptide substrate site of Src providing more specificit ...
1.53 MB
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FOXC1, a target of polycomb, in ...
Polycomb group (PcG) proteins have recently been shown related to cancer development. The PcG protein EZH2 is involved in progression of prostate an ...
614.71 KB
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Loss of Yes-associated protein ...
Yes-associated protein (YAP) is a well characterized transcriptional coactivator that interacts with various transcription factors and modulates the ...
580.58 KB
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Traditional breast cancer risk ...
At least four major categories of invasive breast cancer have been reproducibly identified by gene expression profiling: luminal A, luminal B, HER2- ...
200.03 KB
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The prognostic role of circulat ...
The prognostic significance of circulating tumor cells (CTCs) in patients with breast cancer is controversial. We performed a meta-analysis of publi ...
377.57 KB
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b-Adrenergic receptors (b-AR) r ...
Activation of b-adrenergic receptors (b-AR) drives proangiogenic factor production in several types of cancers. To examine b-AR regulation of breast ...
544.46 KB
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Role of PTEN promoter methylati ...
Tamoxifen (TAM) resistance is a serious clinical problem in the treatment of breast cancer. Here, we found that S-adenosylmethionine (SAM) and DNA m ...
725.64 KB
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SOSTDC1 differentially modulate ...
Sclerostin domain containing 1 (SOSTDC1) protein regulates processes from development to cancer by modulating activity of bone morphogenetic protein ...
381.99 KB
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Soy intake in association with ...
It has been suggested that soy food and its components may relieve menopausal symptoms (MPS) including hot flashes, night sweats, and vaginal drynes ...
224.92 KB
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Co-expression of SNAIL and TWIS ...
Epithelial mesenchymal transition (EMT) plays an important role in the development of metastases. One of the hallmarks of EMT is loss of E-cadherin ...
585.62 KB
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Common genetic polymorphisms of ...
Recent compelling evidence indicates that mutation, aberrant expression, and dysregulation of microRNA (miRNA) biogenesis are implicated in cancer ...
225.79 KB
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A SEER-Medicare population-base ...
Each year there are an estimated 200,000 new breast cancer cases diagnosed in the United States; of these, 1% of cases are in men. Lymphedema can be ...
202.30 KB
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Different CHEK2 germline mutati ...
Germline mutations in BRCA1 were already linked to basal-like subtype of immunophenotypic molecular classification of breast cancer (BC). However, i ...
213.21 KB
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Gene expression profile testing ...
As gene expression profile (GEP) testing for breast cancer may provide additional prognostic information to guide the use of adjuvant chemotherapy, ...
192.06 KB
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Predictors of timing of adjuvan ...
Adherence to consensus guidelines for cancer care may vary widely across health care settings and contribute to differences in cancer outcomes. For ...
221.25 KB
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Identification of the receptor ...
The identification of molecular features that contribute to the progression of breast cancer can provide valuable insight into the pathogenesis of t ...
912.26 KB
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A prognostic model for lymph no ...
model for a more precise prognosis of the risk of relapse is needed to avoid overtreatment of lymph node-negative breast cancer patients. A large de ...
786.25 KB
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Characterisation of unclassifie ...
subset of the unclassified variants (UVs) identified during genetic screening of BRCA1/2 genes may affect splicing. We assessed at RNA level the eff ...
1.03 MB
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Prevalence and characterization ...
Although there are some studies to investigate germline mutations in BRCA1/2 genes in Chinese women with familial breast cancer, many of them suffer ...
216.98 KB
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Transcriptomic and proteomic pr ...
Sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables, is a potent inhibitor of experimental mammary carcinogenesis and may be an ef ...
600.50 KB
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Absenteeism and short-term disa ...
Few data exist related to the impact of breast cancer on work absenteeism and short-term disability. This retrospective study estimated the extent a ...
277.08 KB
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Overexpression of ligase defect ...
E6-associated protein (E6-AP) is a dual function protein. It acts as an E3 ubiquitin-protein ligase enzyme and coactivator of steroid hormone recept ...
1.36 MB
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COX2 overexpression is a progno ...
To determine the significance of (Cyclooxygenase 2) COX2 for clinical outcome in breast cancer, we analyzed the correlation between COX2 overexpress ...
509.44 KB
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FOXA1 is an independent prognos ...
Forkhead box protein A1 (FOXA1) is a ‘‘pioneer factor’’ that plays a role in controlling nearly 50% of estrogen receptor target genes. FOXA1 express ...
434.05 KB
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Hematogenous and lymphatic tumo ...
Tumor cell dissemination in bone marrow (BM) and lymph nodes is considered an important step in systemic disease progression and is associated with ...
400.88 KB
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