Genetic susceptibility to renal scar formation after ur ...
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Genetic susceptibility to renal ...
Identifying patients who may develop renal scarring after urinary tract infections (UTI) remains challenging, as clinical determinants explain only ...
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Problems with 'focal segme ...
The term 'focal segmental glomerulosclerosis (FSGS)' has been applied to many different conditions. All classifications of 'FSGS', including those d ...
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Control of mammalian kidney dev ...
The kidney is the most common site of congenital malformations that result in impaired renal function. Yet, the molecular mechanisms that control re ...
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Vitamin D, chronic kidney disea ...
It is now about 40 years ago that the mechanism of renal 1-ل-hydroxylation of vitamin D was discovered and characterized. After this seminal observa ...
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Nephronophthisis
Nephronophthisis (NPHP) is an autosomal recessive cystic kidney disease and the most frequent genetic cause of end-stage renal disease up to the thi ...
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The genetic components of idiop ...
Nephrolithiasis is a cause of significant morbidity and medical care expenses worldwide. Its prevalence has increased steadily during the last three ...
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Advances in our understanding o ...
Glomerular thrombotic microangiopathy is a hallmark feature of haemolytic uraemic syndrome, the leading cause of acute renal failure in childhood. T ...
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Aciclovir and Varicella-zoster- ...
Clear recommendations for the management of acute varicella-zoster virus (VZV) infections for cases of significant exposure and the use of prophylac ...
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Uraemic vasculopathy in childre ...
Since the inception of pediatric dialysis programmes nearly 50 years ago, there have been vast improvements in both the technology and expertise in ...
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Heat shock proteins in chronic ...
Heat shock proteins (HSP) form a heterogenous, evolutionarily conserved group of molecules with high sequence homology. They mainly act as intracell ...
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Nocturnal enuresis—theoretic ba ...
Nocturnal polyuria, nocturnal detrusor overactivity and high arousal thresholds are central in the pathogenesis of enuresis. An underlying mechanism ...
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Role of fibroblast growth facto ...
Fibroblast growth factor receptors (Fgfrs) are expressed throughout the developing kidney. Several early studies have shown that exogenous fibroblas ...
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Consequences and therapy of the ...
Metabolic acidosis is common in patients with chronic kidney disease (CKD), particularly once the glomerular filtration rate (GFR) falls below 25 ml ...
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Parathyroid hormone and growth ...
Growth failure is common in children with chronic kidney disease, and successful treatment is a major challenge in the management of these children. ...
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PPARم and chronic kidney diseas ...
Peroxisome proliferator-activated receptor-م (PPARم) agonists, exemplified by the thiazolidinediones (TZDs), have been used extensively for their be ...
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Management of toxic ingestions ...
Although rare, renal replacement therapy (RRT) for the treatment of the metabolic, respiratory and hemodynamic complications of intoxications may be ...
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Diagnosis and management of chi ...
A number of syndromic disorders have renal cysts as a component of their phenotypes. These disorders can generally be distinguished from autosomal d ...
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Intradialytic hypotension
Intradialytic hypotension (IDH) is common in children during conventional, 4 hour haemodialysis (HD) sessions. The declining blood pressure (BP) was ...
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Ciliopathies: an expanding dise ...
Ciliopathies comprise a group of disorders associated with genetic mutations encoding defective proteins, which result in either abnormal formation ...
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Renal amyloidosis in children
Renal amyloidosis is a detrimental disease caused by the deposition of amyloid fibrils. A child with renal amyloidosis may present with proteinuria ...
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Biomarkers of acute kidney inju ...
Acute kidney injury (AKI) in children is associated with increased mortality and prolonged length of hospital stay and may also be associated with l ...
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Cystinosis: practical tools for ...
Cystinosis is the major cause of inherited Fanconi syndrome, and should be suspected in young children with failure to thrive and signs of renal pro ...
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Genetics of congenital anomalie ...
Congenital anomalies of the kidney and urinary tract (CAKUT) occur in 1 in 500 births and are a major cause of morbidity in children. Notably, CAKUT ...
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Abdominal pain in a female adol ...
A 16-year-old white female presented to the emergency department (ED) with complaints of multiple episodes of vomiting, colicky left flank, and lowe ...
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Dent’s disease: clinical featur ...
Dent’s disease is an X-linked recessive renal tubulopathy characterized by low-molecular-weight proteinuria (LMWP), hypercalciuria, nephrocalcinosis ...
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