Increased production and recovery of secreted foreign p ...
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Increased production and recove ...
Although plant cell cultures can be used to produce a variety of proteins, the instability and degradation of secreted proteins hinders product recov ...
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Toward Elucidating the Full Spe ...
Our research has focused on the molecular design of immunotherapeutic vaccines and the advancement of mite-allergy diagnosis. Here, we describe the r ...
1.98 MB
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Effect of Static Pressure on Hu ...
The effect of static pressure on the production of human granulocyte-macrophage colony stimulating factor (hGM-CSF) by the Chinese hamster ovary (CHO ...
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Comparison of the response of p ...
The response of primary human peripheral blood mononuclear phagocytes to challenge with polyethylene particles of known size and dose was evaluated. ...
1.18 MB
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Regulation of p53 Localization ...
The abundance and activity of p53 are regulated largely by ubiquitin ligases. Here we demonstrate a previously undisclosed regulation of p53 localiza ...
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In vitro cytokine production by ...
The authors evaluated the ability of bone cement to modify the pro"le of pro-in#ammatory cytokines secreted by the immune cells. Peripheral blood mon ...
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Cytokine release in mononuclear ...
The aim of this study was the evaluation of the release of bone-resorbing cytokines in peripheral blood mononuclear cells (PBMC) of patients with ase ...
225.82 KB
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Mathematical model of heat tran ...
We present a mathematical model that describes heat and mass transfer during solid-state fermentation (SSF) of Aspergillus oryzae in a well-mixed rot ...
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Burned-Out Testicular Tumor:A C ...
Germ cell tumors constitute the majority of all testicular tumors, which are relatively rare overall and are mainly encountered in young adults and t ...
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Genetic Manipulation to Identif ...
We have identified the bottleneck steps limiting expression of penicillin acylase (PAC) through comparison of the expression performance for various ...
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282.67 KB
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Biodegradable laminar implants ...
Due to its short half-life, renal toxicity and necessity for daily subcutaneous injections, recombinant human growth hormone (rhGH) would best be adm ...
116.82 KB
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Factors a!ecting the degradatio ...
The purpose of this work was to study the degradation of poly(lactide-co-glycolide) (PLG) microspheres in vivo and in vitro. Degradation rate constan ...
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study of the scale-up of revers ...
A general rate model for liquid chromatography which considers nonlinear isotherms and various mass transfer effects, including axial dispersion, int ...
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1.42 MB
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Sustained delivery of human gro ...
Purpose: The purpose of this study was to evaluate the release of recombinant human growth hormone (rhGH) from a novel nonpolymeric sustained release ...
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Synthesis, characterization and ...
A series of poly(D,L-lactic-co-glycolic acid) (PLGA):poly(ethyleneglycol) (PEG) di-block copolymers were synthesized by ring-opening polymerization o ...
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169.11 KB
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Degradable dextran hydrogels: c ...
The preparation of protein-loaded degradable hydroxyethyl methacrylated dextran (dex-HEMA) hydrogels, cylindrical macroscopic gels as well as microsp ...
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Effects of acrylic acid on prep ...
Dextran hydrogels were obtained by radical copolymerization of methacrylated dextran (MA-dextran) with acrylic acid (AAc) using ammonium peroxydisulf ...
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Kinetic Model of in vivo Foldin ...
Aggregation of misfolded proteins can reduce the yield in recombinant protein production. The underlying complex processes are additionally influenc ...
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Thrombotic Thrombocytopenic Pur ...
Thrombotic thrombocytopenic purpura (TTP) is a rare and life-threatening complication of gemcitabine treatment. Since the approval of this nucleoside ...
216.19 KB
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Influence of Scale-Up on the Qu ...
The aerobic fed-batch production of recombinant human growth hormone (rhGH) by Escherichia coli was studied. The goal was to determine the productio ...
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Thermodynamic studies of pressu ...
and temperature at both low(19 bar) and high (318 bar) pressures using a homologous series of hydrophobic poly-l-phenylalanine (n = 2–7) as the model ...
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The accuracy and precision of a ...
Recently, we developed a new method for measuring the thermodynamic stability of proteins. The method, termed Stability of Unpurified Proteins from R ...
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Protein–polysaccharide interact ...
If the most important parameters affecting protein–polysaccharide interactions are now well documented, recent advances concern the structure-buildin ...
1.12 MB
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Polymer thermodynamics of adsor ...
Since proteins are polymers, their adsorption at interfaces should share some common features with polymers whose adsorption behavior is being rather ...
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C omplex formation of a calcium ...
The elution of FLAG-fusions (an octapeptide with the sequence DYKDDDDK) from immobilized anti-FLAG antibody M1 cannot be explained by a switch of the ...
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