HIV Management: New Approaches
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Molecular Docking Algorithms
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HIV Management: New Approaches
Development of resistance towards currently used anti-HIV drugs is an important determinant in the classical drug failure. Mutations located in the e ...
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Human Leptin Regulation and Pro ...
In rodents leptin inhibits food intake, stimulates energy expenditure, reverses obesity, ameliorates insulin resistance, and accelerates sexual matur ...
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Ibopamine Stimulates ..-Adrener ...
Ibopamine stimulates ..-adrenergic receptors and D1-dopaminergic receptors in the eye. Ibopamine is a dopamine analogue and it is hydrolysed to epini ...
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Immune Mechanisms and Novel Pha ...
Ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury (AKI) and both innate and adaptive immunity contribute to the pathogenesis. ...
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Development of PCR assay for ea ...
Background: Cytomegalovirus (CMV) is an important viral pathogen in patients undergoing organ transplantation. Objectives: We aimed to develop a mol ...
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Immunomodulating Anticancer Alk ...
CY and L-PAM potentiated specific anti-tumor response in addition to their killing effect. The immunomodulating effect of a low dose of either CY or ...
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In Silico and In Vitro: Identif ...
Drug development is a high cost and laborious process, requiring a number of tests until a drug is made available in the market. Therefore, the use o ...
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Incretin-Based Therapies in Pat ...
Type 2 diabetes mellitus (T2DM) is a highly prevalent and progressive metabolic disease associated with significant morbidity and mortality. While gl ...
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Inflammatory Systemic Biomarker ...
Clinicians have used additional tools to aid clinical assessment and to enhance their ability to identify the “vulnerable” patient at risk for cardio ...
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Interactions Between Advanced G ...
Diabetes, is a metabolic disorder characterised by chronic hyperglycaemia, hypertension, dyslipidaemia, microalbuminuria and inflammation. Moreover, ...
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Intercalation of Erlotinib and ...
Both the multi-targeted antifolate pemetrexed and the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) erlotinib have establis ...
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Involvement of the Toxic AGEs ( ...
Diabetic vascular complications are leading causes of acquired blindness, end-stage renal failure, a variety of neuropathies, and accelerated atheros ...
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Linear Interaction Energy (LIE) ...
Currently, in order to accelerate the process of drug development and also reduce costs, many of the experimental assays related to lead discovery an ...
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Mechanisms of Action and Chemic ...
After a long initial stage obscured by empirism and misconceptions, oxygen-ozonetherapy has now become a scientific discipline where the reactions be ...
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Evaluation of the Level of HBV ...
Background and Aims: Hepatitis B infection is a serious public health problem worldwide. It has been shown that the levels of antibody to hepatitis B ...
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Metabotropic Glutamate Receptor ...
Multiple in vivo and in vitro studies show that excessive release of glutamate, and subsequent activation of ionotropic glutamate receptors (iGluRs) ...
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MicroRNA-21: From Cancer to Car ...
MicroRNA-21 (miR-21) expression is activated in multiple types of cancers, such as breast, liver, brain, prostate, myometrial cancers but also in car ...
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Molecular Docking Algorithms
By means of virtual screening of small molecules databases it is possible to identify new potential inhibitors against a target of interest. Molecula ...
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Molecular Modeling as a Tool fo ...
With the progression of structural genomics projects, comparative modeling remains an increasingly important method of choice to obtain 3D structure ...
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Molecular Recognition Models: A ...
Molecular recognition process describes the interaction involving two molecules. In the case of biomolecules, these pairs of molecules could be prote ...
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Molecular Targets in Malignant ...
Malignant mesothelioma is an aggressive tumour of the serosal surfaces with poor prognosis and increasing incidence due to widespread previous asbest ...
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Monoclonal Antibodies in the Tr ...
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by B cell hyperactivity and defective T-cell function, with production of h ...
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Nanogel Engineered Polymeric Mi ...
In the past few decades nanotechnology for drug delivery has attracted a great deal of attention. Nanogels under this category are sub-micron sized w ...
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New Targets for Therapy in Poly ...
The polyglutamine (polyQ) repeat disorders are a family of inherited disorders characterized by progressive neurodegeneration, as well as the formati ...
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Novel Imaging Techniques in Acu ...
Imaging of the kidneys can provide valuable information in the work up and management of acute kidney injury. Several different imaging modalities ar ...
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