Dual targeting of EphA2 and ER restores tamoxifen sensi ...
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Dual targeting of EphA2 and ER ...
Overexpression and altered function of EphA2 receptor tyrosine kinase are critical in the progression of breast cancer and provide a target for brea ...
448.39 KB
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Overexpression of the urokinase ...
uPAR, the three-domain membrane receptor of the serine protease urokinase, plays a crucial role in tumor growth and metastasis. Several mRNA splice ...
426.76 KB
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The benefits of discussing adju ...
Breast cancer patients must often decide between multiple adjuvant therapy options to prevent cancer recurrence. Standard practice, as implemented i ...
417.47 KB
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Glycodelin expression associate ...
Glycodelin (encoded by PAEP gene) is a secreted lipocalin protein mainly expressed in reproductive tissues, but also in several tumour types. In the ...
254.00 KB
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Declining melatonin levels and ...
Serum melatonin (MLT) levels have been reported to diminish significantly by the 5th and 6th decades of life as the incidence of breast cancer incre ...
388.37 KB
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Epirubicin and paclitaxel with ...
An increased dose-intensity can be achieved by either higher dose of chemotherapy per cycle (dose-escalation) or by shortening the interval between ...
209.83 KB
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Socioeconomic differences in su ...
There seem to be socioeconomically differences in survival for females with breast cancer, usually associated with a higher stage of disease. Howeve ...
242.60 KB
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The effect of various vitamin D ...
Vitamin D deficiency in the patients treated for breast cancer is associated with numerous adverse effects (bone loss, arthralgia, and falls). The f ...
188.48 KB
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Age-related variation in the re ...
Multiple past studies have reported a reduced risk of breast cancer-related mortality (BCM) in relation to pre-diagnostic use of hormone therapy (HT ...
206.29 KB
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Different gene expressions are ...
The goal of this study was to determine whether gene expression differences exist between inflammatory breast cancers (IBC) and T stage-matched non- ...
295.65 KB
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Sentinel node micrometastases i ...
Sentinel node biopsy (SNB) for axillary staging in breast cancer allows the application of more extensive pathologic examination techniques. Microme ...
821.26 KB
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Fragment c gamma receptor gene ...
Previous studies showing the presence of antibodies against tumor-associated antigens in healthy individuals suggest that antibody-dependent cell cy ...
185.59 KB
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Comparative effectiveness of sc ...
Comparative effectiveness research has become an integral part of health care planning in most developed countries. In a simulated cohort of women, ...
268.04 KB
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Oncological and cosmetic outcom ...
An inappropriate skin incision on the breast reduces the cosmetic benefit of breast-conserving surgery (BCS). To improve the cosmetic outcome, we ha ...
451.70 KB
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Combination of the proliferatio ...
Global gene expression profiles, consisting mainly of genes associated with proliferation, have been shown to subdivide histological grade 2 breast ...
291.70 KB
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b-Adrenergic receptors (b-AR) r ...
Activation of b-adrenergic receptors (b-AR) drives proangiogenic factor production in several types of cancers. To examine b-AR regulation of breast ...
544.46 KB
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A prognostic model for lymph no ...
model for a more precise prognosis of the risk of relapse is needed to avoid overtreatment of lymph node-negative breast cancer patients. A large de ...
786.25 KB
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Characterisation of unclassifie ...
subset of the unclassified variants (UVs) identified during genetic screening of BRCA1/2 genes may affect splicing. We assessed at RNA level the eff ...
1.03 MB
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Transcriptomic and proteomic pr ...
Sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables, is a potent inhibitor of experimental mammary carcinogenesis and may be an ef ...
600.50 KB
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Enhancement of chemotherapeutic ...
A subset of primary breast cancers and breast cancer cell lines express a hypermethylation defect (characterized by DNMT hyperactivity and DNMT3b ov ...
639.94 KB
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Identification of a new complex ...
In this study, we present a novel complex rearrangement in the BRCA1 gene. The genomic rearrangement was identified using one of the two commerciall ...
229.28 KB
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Cancer predisposing BARD1 mutat ...
The breast cancer susceptibility gene BARD1 (BRCA1-associated RING domain protein, MIM# 601593) acts with BRCA1 in DNA double-strand break (DSB) re ...
523.62 KB
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Addition of a histone deacetyla ...
Modulation of estrogen signaling is one of the most successful modalities for the treatment of estrogen receptor (ER)-positive breast cancer, yet de ...
556.72 KB
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Significance of ER–Src axis in ...
The estrogen receptor (ER) is implicated in the progression of breast cancer. Despite positive effects of hormonal therapy, initial or acquired resi ...
674.49 KB
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Incidence of chemotherapy-induc ...
Background The purpose of this study was to determine the incidence of amenorrhea among breast cancer patients aged 40 years and younger following a ...
229.25 KB
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