Case series of perimenopausal women with insomnia treat ...
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Case series of perimenopausal w ...
off label for insomnia in perimenopausal women. Despite its apparent efficacy, mirtazapine causes significant increases in appetite and weight gain. ...
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Angiotensin II signaling up-reg ...
The atria respond to various pathological stimuli including pressure and volume overload with remodeling and dilatation. Dilatation of the left atri ...
583.37 KB
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Role of endothelial Nox2 NADPH ...
NADPH oxidase (Nox)-derived reactive oxygen species (ROS) are known to be involved in angiotensin II-induced hypertension and endothelial dysfunctio ...
928.37 KB
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Altered circadian rhythm of car ...
Circadian rhythms influence the incidence of adverse cardiac events but the underlying mechanisms are not well defined. We sought to investigate the ...
1.96 MB
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Conserved expression and functi ...
PDE4 isoenzymes are critical in the control of cAMP signaling in rodent cardiac myocytes. Ablation of PDE4 affects multiple key players in excitatio ...
646.76 KB
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The TIR/BB-loop mimetic AS-1 pr ...
Activation of NF-jB contributes to cardiac hypertrophy and the interleukin-1 receptor (IL-1R)-mediated MyD88-dependent signaling pathway predominate ...
750.78 KB
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Ischemia/reperfusion injury is ...
We hypothesized that nandrolone (ND)-abuse induces cardiac hypertrophy, increases myocardial susceptibility to ischemia/reperfusion (I/R) injury, an ...
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612.50 KB
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Desmoglein 2 mutant mice develo ...
Desmosomes are cell–cell adhesion sites and part of the intercalated discs, which couple adjacent cardiomyocytes. The connection is formed by the ex ...
2.03 MB
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Acute vasomotor paralysis and p ...
Implantation of bare metal stents (BMS) induces the release not only of particulate debris, but also of soluble vasoconstrictors which contribute to ...
454.47 KB
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Safety of avoiding routine use ...
Physicians are moving away from routine axillary lymph node dissection (ALND) in clinically nodenegative breast cancer. We conducted a systemic revi ...
257.03 KB
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Patterns and incidence of chrom ...
One of the hallmarks of human solid tumors is chromosomal instability (CIN). We studied global patterns as well as individual levels of CIN and dete ...
459.87 KB
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Toremifene is an effective and ...
Compared to tamoxifen, the efficacy and side effects of toremifene in adjuvant endocrine therapy for breast cancer were not very clear. This meta-an ...
375.00 KB
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Mutations and polymorphic BRCA ...
We previously showed that about 80% of breast cancer patients at high risk to carry mutation in BRCA genes presented at least one polymorphism in th ...
227.69 KB
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RAD51 135G>C does not modify ...
A single-nucleotide polymorphism (SNP) in the 50-untranslated region (UTR) of RAD51, 135G[C (rs1801320), was reported to be associated with an incre ...
288.97 KB
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Clinicopathologic and molecular ...
Akt/PKB serine/threonine kinase is a leading signalling modulator for several cellular processes including metabolism, growth, proliferation and sur ...
375.75 KB
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Pure flat epithelial atypia (DI ...
Flat epithelial atypia (FEA) is recognized as a precursor of breast cancer and its management (surgical excision or intensive follow-up) remains unc ...
169.49 KB
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Phase I trial of oral mTOR inhi ...
To determine the feasible dose and schedule for everolimus, an oral mTOR inhibitor, combined with vinorelbine and trastuzumab for patients with HER2 ...
326.50 KB
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Let-7a regulation of insulin-li ...
Expression of certain microRNA genes is regulated by DNA methylation, which in turn affects the activities of their downstream molecules. Our previo ...
226.01 KB
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Randomized, double-blind compar ...
Near-infrared (NIR) fluorescence imaging has the potential to improve sentinel lymph node (SLN) mapping in breast cancer. Indocyanine green (ICG) is ...
319.06 KB
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Increased risk of contralateral ...
Breast cancer (BC) survivors are at increased risk of second cancers. Obesity is commonly recognized as a risk factor of BC in postmenopausal period ...
377.64 KB
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Image-guided sampling reveals i ...
Mammographic density (MD) adjusted for age and body mass index (BMI) is a strong heritable breast cancer risk factor; however, its biological basis ...
658.87 KB
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Chemotherapy characteristics ar ...
Chemotherapy is vital for breast cancer management, but early onset toxicities like neutropenia hinder its administration. Primary prophylactic (PP) ...
368.13 KB
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Association of diagnostic work- ...
The objective of this study is to determine whether the likelihood of returning for routine breast cancer screening differed for false-positive case ...
195.98 KB
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Genetic variants within miR-126 ...
MicroRNAs (miRNAs) are 20–22 nt non-coding RNAs which promote the degradation of target mRNAs or repression of the translation of mRNAs by sequence ...
219.54 KB
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HER2 status in a population-der ...
This retrospective study investigates the correlation of intra-individual HER2 status between primary breast cancers and corresponding recurrences i ...
362.19 KB
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