Pharmacological Characteristics and Clinical Applicatio ...
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Getting a Grip on Complexes
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Pharmacological Characteristics ...
K201 is a 1,4-benzothiazepine derivative that is a promising new drug with a strong cardioprotective effect. We initially discovered K201 as an effec ...
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The Biology of TRAIL and the Ro ...
TNF-related apoptosis inducing ligand (TRAIL) is a key mediator of the innate immune response to infection. While TRAIL-mediated apoptosis plays an e ...
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Potential Uses of MicroRNA in L ...
Lung cancer is the leading cause of death from cancer in the world. Although the molecular network of lung carcinogenesis has been partly known at th ...
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Potential of DNMT and its Epige ...
Lung cancer, the leading cause of mortality in both men and women in the United States, is largely diagnosed at its advanced stages that there are no ...
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Hidden Markov Models and their ...
Hidden Markov models (HMMs) have been extensively used in biological sequence analysis. In this paper, we give a tutorial review of HMMs and their ap ...
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Two Diseases with One Hit: Inhi ...
Obesity is a well-recognized cancer risk factor. The increase in risk for colorectal, endometrial, breast and esophageal cancers associated with obes ...
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Recent Advances in Intervention ...
Markovian regulatory networks constitute a class of discrete state-space models used to study gene regulatory dynamics and discover methods that bene ...
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Performance of Feature Selectio ...
High-throughput biological technologies offer the promise of finding feature sets to serve as biomarkers for medical applications; however, the sheer ...
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Activated Protein C and Acute K ...
Protein C is a plasma serine protease that when activated plays a central role in modulating the function of the vascular endothelium and its interfa ...
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Functional Characterization of ...
Chitin and its deacetylated derivative chitosan are natural polymers composed of randomly distributed ..-(1-4)- linked D-glucosamine (deacetylated un ...
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Classification and Error Estima ...
Discrete classification is common in Genomic Signal Processing applications, in particular in classification of discretized gene expression data, and ...
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Tumor Systems Need to be Render ...
Background: A tumor system not only consists of diverse cell types but also comprises all components of action insofar that these components are orie ...
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Baseline MRI Predictors of Conv ...
The Alzheimer’s Disease Neuroimaging Initiative (ADNI) is a multi-center study assessing neuroimaging in diagnosis and longitudinal monitoring. Amnes ...
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p53 isoform D113p53 is a p53 ta ...
p53 is a well-known tumor suppressor and is also involved in processes of organismal aging and developmental control. A recent exciting development i ...
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Clustering Algorithms: On Learn ...
The development of microarray technology has enabled scientists to measure the expression of thousands of genes simultaneously, resulting in a surge ...
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Review of Peak Detection Algori ...
In this review, we will discuss peak detection in Liquid-Chromatography-Mass Spectrometry (LC/MS) from a signal processing perspective. A brief intro ...
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Getting a Grip on Complexes
We are witnessing tremendous advances in our understanding of the organization of life. Complete genomes are being deciphered with ever increasing sp ...
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Composition and Functions of th ...
Fusion of the influenza virus envelope with the endosomal membrane of host cells is mediated by the hemagglutinin glycoprotein (HA). The most conserv ...
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Perspectives in Cell Cycle Regu ...
The ability of an animal, normally dependent on aerobic respiration, to suspend breathing and enter an anoxic state for long term survival is clearly ...
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High-Throughput Genomics Enhanc ...
Tomato (Solanum lycopersicum) is considered a model plant species for a group of economically important crops, such as potato, pepper, eggplant, sinc ...
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Krüppel-Like Factors 4 and 5: U ...
Krüppel-like factors (Klf) 4 and 5 belong to a family of zinc finger-containing transcription factors that share homology with the Drosophila gene Kr ...
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MDM4 (MDMX) and its Transcript ...
MDM family proteins are crucial regulators of the oncosuppressor p53. Alterations of their gene status, mainly amplification events, have been freque ...
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Advances in Genetical Genomics ...
Natural variation provides a valuable resource to study the genetic regulation of quantitative traits. In quantitative trait locus (QTL) analyses thi ...
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Mechanisms and Signals for the ...
In eukaryotes, the nuclear membrane provides a physical barrier to the passive diffusion of macromolecules from and into the cytoplasm. Nucleocytopla ...
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Molecular Pathophysiology of Re ...
Renal tubular acidosis (RTA) is characterized by metabolic acidosis due to renal impaired acid excretion. Hyperchloremic acidosis with normal anion g ...
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