In Silico and In Vitro: Identifying New Drugs
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In Silico and In Vitro: Identif ...
Drug development is a high cost and laborious process, requiring a number of tests until a drug is made available in the market. Therefore, the use o ...
223.44 KB
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Genetically Modified Hepatitis ...
The surface antigen of hepatitis B virus (HBsAg) spontaneously aggregates into ‘empty’ virus-like particles (VLPs) in the absence of other viral comp ...
246.35 KB
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Experimental Approaches to Eval ...
Precise experimental methods to determine ligand-binding affinity are needed to accelerate the discovery of new drugs. Assessing protein-ligand inter ...
237.49 KB
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Evaluation of Molecular Docking ...
Molecular docking simulations are of pivotal importance for analysis of protein-ligand interactions and also an essential resource for virtual-screen ...
476.54 KB
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Drug-Binding Databases
Recent developments in computer power and chemoinformatics methodology make possible that a huge amount of data become available through internet. Th ...
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Current Advances in the Develop ...
Protein kinases, either membrane-embedded receptorial or cytosolic non-receptorial ones, are important transducers of cell proliferation signals. In ...
758.87 KB
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Computational Methods for Calcu ...
Precise computational methods to determine ligand-binding affinity are needed to accelerate the discovery of new drugs. Assessing protein-ligand inte ...
347.98 KB
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Synthesis, Characterisation, An ...
A facile synthesis and characterisation of novel dispiro-oxindolopyrrolidines is delineated. The results of the anti-microbial studies of novel dispi ...
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Chemical Biology: Past, Present ...
Chemical biology (CB) is a scientific discipline spanning the fields of chemistry and biology involving the application of chemical techniques and to ...
536.08 KB
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Single Molecule Studies in Chem ...
Modern ultra-sensitive instrumental skill and expertise on surface modification of single biological molecules have sharpened the capabilities of sci ...
1.09 MB
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Relationship Between Metal Tran ...
Trace elements as Cu (copper), Fe (iron), and Zn (zinc) can be toxic when their distribution is not carefully regulated, and also their inappropriate ...
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N-Terminal Specific Fluorescenc ...
The function of a protein correlates closely with its structure; even partial structural disorder/misfolding may lead to various diseases such as Par ...
780.55 KB
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Enzymes with Phosphotriesterase ...
Organophosphates (OPs) are a class of synthetic compounds used both as pesticides and nerve agents. They are chemically phosphoesters and biologicall ...
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Cause of Chirality Consensus
Biological macromolecules, proteins and nucleic acids are composed exclusively of chirally pure monomers. The chirality consensus appears vital for l ...
231.92 KB
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Molecular Kinetics and Targetin ...
Protein mobility, chromatin movement and the formation of molecular assemblies in the cell nucleus have, until fairly recently, been viewed in a pseu ...
777.61 KB
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Advancements in Predictive In S ...
This comprehensive review describes contemporary computational (in silico) quantitative structure-activity relationship (QSAR) approaches that have b ...
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A Micro-fluidic System for the ...
We present a new technique for the evaluation of polymer blood compatibility that makes use of a microchannel array flow analyzer and we describe and ...
2.02 MB
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Modulation of Polyamine Biosynt ...
Ornithine decarboxylase (ODC) is a cytosolic enzyme that catalyses the direct decarboxylation of L-ornithine to putrescine, one of the rate-limiting ...
1.18 MB
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Synthesis and Purification of H ...
Some biotechnological inventions involve expensive, sophisticated machines. Others are relatively simple innovations that nevertheless address, and s ...
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Recent Biotechnological Applica ...
Oleosins are naturally occurring, small (15-24 kDa), amphipathic, plant proteins that prevent the coalescence of oil bodies (OBs) during seed and pol ...
1.02 MB
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Cytotoxic Activity of CD48 Mono ...
CD48 is a cell surface, glycosylphosphatidylinositol-linked glycoprotein, and a potential target for treatment of leukemia and lymphoma. Two anti-CD4 ...
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Closed Photobioreactor Assessme ...
Twenty years of Italian outdoor investigations on closed photobioreactors are discussed in this review. Many photobioreactor designs have been projec ...
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Design and Production of Specif ...
Background: A partially random target selection method was developed to design and produce affinity reagents (target) to any protein query. It is bas ...
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A Membrane-Based Flow-through H ...
Genetic diseases remain an important cause of ailment, morbidity and death for children and adults. Despite the recent advances of tools for molecula ...
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Open-Surface Digital Microfluid ...
Open-surface digital microfluidics refers to droplet manipulations in an open surface. Different chemical/ biological reaction protocols can easily b ...
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