Iron overload in MDS—pathophysiology, diagnosis, and co ...
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Leukemia stem cells
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Iron overload in MDS—pathophysi ...
Many patients with myelodysplastic syndromes (MDS) become dependent on blood transfusions and develop transfusional iron overload, which is exacerba ...
367.32 KB
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Leukemia stem cells
Leukemia-initiating cells (LICs) or leukemia stem cells (LSCs) are defined by their ability to form tumors after xenotransplantation in immunodefici ...
813.02 KB
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Anemia—still a major health pro ...
Anemia is a major global health problem, especially in developing countries. This fundamental health issue still has not been solved and continues t ...
167.12 KB
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CD44 in hematological neoplasia ...
The CD44 protein family spans a large group of transmembrane glycoproteins acquired by alternative splicing and post-translational modifications. Th ...
374.25 KB
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Expansion of CD4+CD25+ regulato ...
Rapamycin has important roles in the modulation of regulatory T cells. We tried to expand CD4+CD25+ regulatory T cells (Treg cells) from umbilical c ...
269.55 KB
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Quantitative analysis of Hb Bar ...
It has long been recognized that the presence of hemoglobin (Hb) Bart’s in newborn’s blood is associated with α-thalassemia. However, the automated ...
311.20 KB
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Prolonged transendothelial migr ...
The therapeutic success of haematopoetic stem and progenitor cell (HSPC) transplantation is critically dependent on HSPC engraftment in the bone mar ...
298.61 KB
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The impact of treatment, socio- ...
Cancer survivors are at risk of experiencing adverse physical and psychosocial effects of their cancer and its treatment. Both Hodgkin’s lymphoma (H ...
258.63 KB
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Formation of an adherent hemato ...
Expansion of transplantable cord blood (CB) progenitors using a stroma requires provision of an exogenous cell source because of the low frequency o ...
747.11 KB
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Deferasirox effectively decreas ...
Iron overload is present in several cases of double heterozygous sickle-cell/beta-thalassemia (HbS/β-thal). Deferasirox is an orally administered ir ...
136.38 KB
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Dysmetabolic hyperferritinemia ...
Hyperferritinemia is common in individuals with the metabolic syndrome (dysmetabolic hyperferritinemia), but its pathophysiology and the degree to w ...
99.71 KB
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Myeloid growth factors in acute ...
Randomized controlled trials (RCT) investigating administration of colony-stimulating factors (CSF) during or after chemotherapy in acute myeloid le ...
404.43 KB
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Hydralazine and magnesium valpr ...
Decitabine and azacitidine, two DNA methyltransferase (DNMT) inhibitors, are the current standard of treatment for myelodysplastic syndrome (MDS). H ...
220.92 KB
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Oxidative stress contributes to ...
In the present study, we questioned the role of oxidative stress in hereditary spherocytosis (HS), where red blood cells (RBC) have a shortened surv ...
230.13 KB
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A prospective study to assess t ...
This prospective study was carried out to assess the usefulness of five laboratory tests in the diagnosis of hereditary spherocytosis (HS), based on ...
450.90 KB
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Enhanced activation of autophag ...
Erythropoiesis in β-thalassemia patients is ineffective, primarily because of death of the erythroid progenitor cells at the polychromatic normoblas ...
866.43 KB
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Bone marrow mesenchymal stem ce ...
Adoptive cellular immunotherapy is an important treatment to eliminate residual tumor cells after hematopoietic stem-cell transplantation. Bone marr ...
764.48 KB
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Staurosporine induces megakaryo ...
The induction of megakaryocyte (MK) differentiation is a potent strategy for the clinical treatment of diseases related to blood platelet disorders. ...
955.52 KB
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Cost-effectiveness of adenotons ...
In children with sickle cell disease (SCD), adenotonsillar hypertrophy or recurrent tonsillitis are frequently linked with an increased risk of obst ...
128.78 KB
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Molecular characterization of a ...
Over 80% of the α-thalassemia cases in southern China are caused by large deletions involving the α-globin gene cluster on chromosome 16p13.3. Here, ...
311.81 KB
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Leukemias induced by altered TR ...
Rapamycin is a potent allosteric mTORC1 inhibitor with clinical applications as an anticancer agent. However, only a fraction of cancer patients res ...
597.84 KB
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The role of zinc protoporphyrin ...
The differentiation between primary myelofibrosis (PMF) and essential thrombocythaemia (ET) may be difficult especially in early-stage disease. In P ...
185.47 KB
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Impact of cytokine gene polymor ...
Autoreactive cytotoxic T cells play a key role in the pathogenesis of aplastic anemia (AA) by myelosuppressive cytokines including interferon-gamma, ...
239.30 KB
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Contribution of VKORC1 and CYP2 ...
Within the Asian populations, Indian patients had been reported to require higher warfarin dose compared with the Chinese and Malay patients, and th ...
139.50 KB
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Additional erythrocytic and ret ...
Hereditary spherocytosis (HS) is characterised by weakened vertical linkages between the membrane skeleton and the red blood cell’s lipid bilayer, l ...
341.00 KB
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