Classical membrane progesterone receptors in murine mam ...
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Classical membrane progesterone ...
In this article, we demonstrate the expression of functional progesterone binding sites at the cell membrane in murine mammary carcinomas that are s ...
1.01 MB
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Role of ferritin alterations in ...
Breast cancer is the most common malignancy in women. Successful treatment of breast cancer relies on a better understanding of the molecular mechan ...
405.56 KB
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Clinical significance of high f ...
Increased expression and activation of focal adhesion kinase (FAK) was reported to be an unfavorable factor in various human cancers, including brea ...
467.84 KB
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Overexpression of the urokinase ...
uPAR, the three-domain membrane receptor of the serine protease urokinase, plays a crucial role in tumor growth and metastasis. Several mRNA splice ...
426.76 KB
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Inhibition of focal adhesion ki ...
Acquired resistance to endocrine therapy in breast cancer is a major clinical problem. Previous reports have demonstrated that cell models of acquir ...
558.73 KB
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Dead-box or black-box: is DDX1 ...
In this issue of Breast Cancer Research and Treatment, Germain et al. evaluate the potential role of DEAD-box 1 (DDX1) as an independent marker of p ...
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Presence of Foxp3 expression in ...
The Forkhead Box Protein 3 is highly expressed not only in regulatory T cells, but also in tumor cells, acting as a transcriptional repressor of bre ...
341.44 KB
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The benefits of discussing adju ...
Breast cancer patients must often decide between multiple adjuvant therapy options to prevent cancer recurrence. Standard practice, as implemented i ...
417.47 KB
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The anti-diabetic drug metformi ...
We here demonstrate that the anti-diabetic drug metformin interacts synergistically with the anti-HER2 monoclonal antibody trastuzumab (Tzb; Hercept ...
857.17 KB
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The liver receptor homolog-1 re ...
Estrogen receptor-a (ER) is expressed in the great majority of breast cancers, and the inhibition of ER action is a key part of breast cancer treatm ...
758.44 KB
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High immunogenic potential of p ...
As pre-existent immunity might be a reflection of an emerging anticancer response, the demonstration of spontaneous T-cell responses against tumor a ...
509.61 KB
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The value of preoperative stagi ...
Little is known about the benefits of preoperative staging chest computed tomography (CT) in patients with asymptomatic breast cancer. We therefore ...
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186.23 KB
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The TGF-b/Smad pathway induces ...
Transforming growth factor-b (TGF-b) has opposing roles in breast cancer progression by acting as a tumor suppressor in the initial phase, but stimu ...
640.46 KB
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GRB7 protein over-expression an ...
The growth factor receptor-bound protein-7 gene (GRB7) encodes a multi-domain signal transduction molecule. The purpose of this study was to examine ...
364.17 KB
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COX2 expression in prognosis an ...
In breast cancer, the prognostic impact of COX2 expression varies widely between studies. We examined the prognostic value of COX2 expression in a ...
519.55 KB
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Combined Src and ER blockade im ...
Antiestrogen therapies arrest susceptible estrogen receptor (ER)-positive breast cancers by increasing p27. Since Src phosphorylates p27 to promote ...
573.30 KB
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Let-7 family miRNAs regulate es ...
In order to understand how microRNAs (miRNAs) regulate breast cancer tumorigenesis, a miRNA expression microarray screening was performed using RNA ...
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Interactions between breast can ...
The preferential metastasis of breast cancer cells to bone is a complex set of events including homing and preferential growth which may include uni ...
643.92 KB
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Nicotine-induced human breast c ...
Previous studies have demonstrated that the persistent exposure of human bronchial epithelial cells to nicotine (Nic) through nicotinic acetylcholin ...
795.89 KB
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Clinical application of shear w ...
Shear wave elastography (SWE) is an emerging technique which can obtain quantitative elasticity values in breast disease. We therefore evaluated the ...
540.37 KB
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RAD51 135G>C does not modify ...
A single-nucleotide polymorphism (SNP) in the 50-untranslated region (UTR) of RAD51, 135G[C (rs1801320), was reported to be associated with an incre ...
288.97 KB
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Oral fluoropyrimidine may augme ...
The present preclinical study was designed to evaluate a new combination therapy comprised of the aromatase inhibitor anastrozole (ANA) and the oral ...
526.71 KB
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Three-dimensional collagen repr ...
The behavior of breast epithelial cells is influenced by their microenvironment which includes stromal cells and extracellular matrix (ECM). During ...
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Targeting mutant p53 protein an ...
Breast cancer progression depends upon the elaboration of a vasculature sufficient for the nourishment of the developing tumor. Breast tumor cells f ...
1.07 MB
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Tumor angiogenesis as prognosti ...
The goal of this analysis was to characterize the survival impact of angiogenesis in the patients with highrisk breast cancer, particularly the pred ...
372.19 KB
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