The rexinoid bexarotene represses cyclin D1 transcripti ...
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The rexinoid bexarotene repress ...
Bexarotene is an RXR-selective vitamin A analog that has been shown to prevent ER-negative mammary tumorigenesis in animal models. While investigati ...
دانلود 2
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International distribution and ...
The c.156_157insAlu BRCA2 mutation has so far only been reported in hereditary breast/ovarian cancer (HBOC) families of Portuguese origin. Since thi ...
332.17 KB
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Tumor–stroma ratio in the prima ...
Stroma tissue surrounding cancer cells plays an important role in tumor development and behavior. In colorectal cancer, it has been found that the a ...
413.27 KB
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Prevalence of the variant allel ...
Recently, a variant allele in the 30UTR of the KRAS gene (rs61764370 T[G) was shown to be associated with an increased risk for developing non-small ...
203.35 KB
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Identification of immunodominan ...
Mammaglobin-A (MGBA), a 10-kD protein, is over expressed in 80% of primary and metastatic human breast cancers. Breast cancer patients demonstrate h ...
425.81 KB
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Does radiotherapy planning with ...
This prospective study investigated radiation dose and volume changes during breathing cycle. Ten patients with left breast carcinoma receiving radi ...
630.54 KB
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Targeting trastuzumab-resistant ...
Targeting HER-2 over-expressing breast cancer cells with trastuzumab has resulted in significant improvements in both disease-free and overall survi ...
573.27 KB
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Time for a re-evaluation of mam ...
Mammography in younger women is considered to be of limited value. In a resource restricted environment without access to magnetic resonance imaging ...
182.89 KB
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Vitamin D and aromatase inhibit ...
A double-blind placebo-controlled randomized phase II trial was performed to determine whether High Dose Vitamin D2 supplementation (HDD) in women ...
290.52 KB
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Insulin like growth factor bind ...
Previously, we have shown that insulin-like growth factor binding protein-7 (IGFBP-7) expression is inversely correlated with disease progression in ...
750.15 KB
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Distinct function of androgen r ...
Steroid receptor coactivators are important in regulating the function of the receptors in endocrine organ development and in cancers, including bre ...
1.70 MB
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Clinicopathologic and molecular ...
Akt/PKB serine/threonine kinase is a leading signalling modulator for several cellular processes including metabolism, growth, proliferation and sur ...
375.75 KB
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Enhanced serine production by b ...
Since bone metastatic breast cancer is an incurable disease, causing significant morbidity and mortality, an understanding of the underlying molecul ...
500.10 KB
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Chemotherapy versus tamoxifen v ...
First, to evaluate whether the benefits of combined chemotherapy (CT) and Tamoxifen (T), previously documented in the GROCTA-01 Trial, were long-las ...
535.13 KB
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Image-guided tumor resection us ...
Tumor involvement of resection margins is found in a large proportion of patients who undergo breastconserving surgery. Near-infrared (NIR) fluoresc ...
666.95 KB
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Women’s interest in taking tamo ...
Although tamoxifen can prevent primary breast cancer, few women use it as a preventive measure. A second option, raloxifene, has recently been appro ...
299.87 KB
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Genomics, histopathology, and t ...
Efforts to improve recurrence risk stratification for breast cancer patients have increasingly focused on rapidly developing gene expression profili ...
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Glycodelin expression associate ...
Glycodelin (encoded by PAEP gene) is a secreted lipocalin protein mainly expressed in reproductive tissues, but also in several tumour types. In the ...
254.00 KB
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Declining melatonin levels and ...
Serum melatonin (MLT) levels have been reported to diminish significantly by the 5th and 6th decades of life as the incidence of breast cancer incre ...
388.37 KB
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Phosphorylated S6K1 is a possib ...
Cross-talk between the estrogen receptor and the mammalian target of rapamycin (mTOR) pathway is one of the mechanisms of endocrine therapy resistan ...
371.86 KB
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Zoledronic acid prevents bone l ...
To determine whether zoledronic acid (ZA) can prevent bone loss in premenopausal women undergoing adjuvant chemotherapy for breast cancer. In this r ...
356.46 KB
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Results of a phase II study of ...
Palliation is the primary goal in metastatic breast cancer (MBC), and safe, efficacious, new singleagent options are needed. Pemetrexed, an antifola ...
233.82 KB
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High serum TGF-a predicts poor ...
Lapatinib and capecitabine combination therapy is effective in trastuzumab-resistant human epidermal growth factor receptor 2 (HER2)-positive breast ...
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Inflammatory breast cancer: hig ...
Inflammatory breast cancer (IBC), the most lethal form of breast cancer, has characteristics linked to higher risk of contralateral breast cancer. H ...
253.07 KB
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CD4+ T cells inhibit the neu-sp ...
Studies conducted in animal model of infectious diseases or H-Y antigen model suggest a crucial role for CD4? T cells in providing help for CD8? T-c ...
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