Glutathione S-transferase P1 Ile105Val polymorphism and ...
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Glutathione S-transferase P1 Il ...
Glutathione S-transferase P1 (GSTP1) is involved in a wide range of detoxifying reactions. Any alteration in the structure, function, or expression ...
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No association of polymorphisms ...
The human homolog of the Drosophila Scribble (SCRIB) tumor suppressor gene encodes a protein that regulates apical-basolateral polarity in mammalian ...
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Germline ATM mutational analysi ...
Biallelic inactivation of ATM gene causes the rare autosomal recessive disorder Ataxia-telangiectasia (A-T). Female relatives of A-T patients have a ...
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Individual responses to chemoth ...
Differences in redox homeostatic control between cancer patients may underlie predisposition to drug resistance and toxicities. To evaluate interind ...
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BRIP1, PALB2, and RAD51C mutati ...
Mutations in the recognized breast cancer susceptibility genes BRCA1, BRCA2, TP53, ATM, and CHEK2 account for approximately 20% of hereditary breast ...
234.73 KB
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Vitamin D threshold to prevent ...
Aromatase inhibitor (AI)-associated arthralgia limits adherence to therapy in breast cancer. The pathophysiology may involve vitamin D status. We wi ...
250.60 KB
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A nationwide analysis of incide ...
In this study, we describe the incidence, treatment, and outcome of breast cancer (BC) during the period 1994–2003 in the South-American country of ...
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No evidence for an association ...
Breast cancer represents a serious public health problem worldwide, for its high incidence, morbidity, mortality, and its high cost treatment. It is ...
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LFA-1 gene polymorphisms are as ...
The infiltrative duct carcinoma (IDC) is the most common malignant breast cancer in females and genetic factors appear to play a significant role in ...
دانلود 1
179.82 KB
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Replication of genome-wide disc ...
Genome-wide association studies (GWAS) have identified associations with robust statistical support for influencing breast cancer susceptibility. Mo ...
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The impact of contralateral mas ...
Among women with breast cancer and a BRCA1 or BRCA2 mutation, the lifetime risk of breast cancer may be as high as 40%. Many physicians recommend p ...
133.20 KB
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A high prevalence of BRCA1 muta ...
The Bahamas is a group of islands in the Caribbean with a high incidence of early onset breast cancer. In isolated populations, the identification o ...
185.69 KB
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PARP-1 expression in breast can ...
Despite ongoing trials of PARP inhibitors in the treatment of breast cancer (BC), the extent of poly (ADP-ribose)polymerase-1 (PARP-1) protein expre ...
427.61 KB
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Gene expression array testing o ...
Archived formalin-fixed, paraffin embedded (FFPE) tissues constitute a vast, well-annotated, but underexploited resource for the molecular study of ...
302.55 KB
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Prediagnostic plasma enterolact ...
Experimental and epidemiological studies have suggested that the phytoestrogen enterolactone is associated to biological mechanisms that may have po ...
283.07 KB
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A recombination-based method to ...
Many missense variants in BRCA1 are of unclear clinical significance. Functional and genetic approaches have been proposed for elucidating the clini ...
340.35 KB
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High estrogen receptor expressi ...
One of the most controversial questions in early breast cancer treatment is the need of chemotherapy in patients with estrogen receptor positive dis ...
404.08 KB
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Poly(ADP-ribose) polymerase-1 m ...
Although poly(ADP-ribose) polymerase-1 (PARP1) inhibition is a recent promising therapy in breast cancer, PARP1 expression in this disease is not kn ...
307.72 KB
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Germline mutational analysis of ...
The past two decades have seen steady progress in the field of breast cancer genetics as we continually increase our understanding of how tumorigene ...
174.96 KB
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Two novel variants in the 30UTR ...
For the majority of breast and/or ovarian cancer patients tested for BRCA1/2 genes, mutation screening of the coding regions remains negative. Micro ...
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Identification and characteriza ...
BAF57 is a core subunit present in all mammalian SWI/SNF ATP-dependent chromatin remodeling complexes, which regulates important biological processe ...
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A 10-year follow-up of treatmen ...
We compare long-term outcomes in patients with node negative early stage breast cancer treated with breast radiotherapy (RT) without the axillary RT ...
336.35 KB
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Comprehensive CYP2D6 genotype a ...
The association between CYP2D6 genotype and outcome in breast cancer patients treated with adjuvant tamoxifen remains controversial. We assessed the ...
321.31 KB
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No significant association resu ...
We have read with great interest the article ‘‘No significant association between the TP53 codon 72 polymorphism and breast cancer risk: a meta-anal ...
104.89 KB
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Genome-wide copy number alterat ...
Genomic copy number alterations (CNA) are common in breast cancer. Identifying characteristic CNAs associated with specific breast cancer subtypes i ...
دانلود 1
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