HER2-positive breast cancer cells resistant to trastuzu ...
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HER2-positive breast cancer cel ...
Trastuzumab has changed the prognosis of HER2 positive breast cancers. Despite this progress, resistance to trastuzumab occurs in most patients. New ...
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Leptomeningeal metastases from ...
Leptomeningeal metastasis (LM) usually occurs late during the course of breast cancer. The aim of this study was to characterize the clinical featur ...
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Variation in breast cancer risk ...
Germline mutations in BRCA1/2 confer a high risk of breast cancer (BC), but the magnitude of this risk varies according to various factors. Although ...
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Predictive value of BI-RADS cla ...
In this study, we assessed the positive-predictive value (PPV) of mammography and/or ultrasonography in women age 50 based on recommendations for bi ...
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COX-2 expression predicts worse ...
Some previous studies have found worse prognosis among cyclooxygenase-2 (COX-2)-expressing breast cancers. Aspirin and NSAIDs inhibit COX-2. Three ...
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Biopsy sampling of breast lesio ...
Needle biopsy is now the initial investigation of choice for the pre-operative diagnosis of breast lesions. This includes core needle biopsy (CNB) a ...
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LMTK3 expression in breast canc ...
Interactions between kinases and the estrogen receptor a (ERa) are thought to be a critical signaling pathway in the majority of human breast cancer ...
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Androgen receptor expression in ...
The androgen receptor (AR) has been shown to be of potential prognostic importance in retrospective cohorts. We evaluated immunohistochemical AR exp ...
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The role of topoisomerase IIa i ...
Topoisomerase IIa is not only a proliferation marker of tumor cells, but is also a target for anthracyclinebased chemotherapy. Both in vitro and in ...
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First generation prognostic gen ...
The aims of this study were to compare the performance of six different genomic prognostic markers to predict long-term survival and chemotherapy re ...
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Age-specific trends of survival ...
Treatment of metastatic breast cancer (MBC) has evolved during the last decades but it is largely unknown whether this has led to improved survival ...
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Pathological characteristics of ...
The immunophenotype of BRCA-associated breast cancer has been studied in predominantly non-Hispanic whites (NHW). We evaluated the pathological char ...
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Effect of primary prophylactic ...
Effective systemic therapy is vital for successful breast cancer treatment, but early onset toxicities like neutropenia hinder systemic therapy admi ...
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Multivitamin use and breast can ...
Little is known about the relation of multivitamin use to breast cancer outcomes. 2,236 women diagnosed from 1997 to 2000 with early-stage breast ca ...
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Prolonged mammosphere culture o ...
Mammosphere culture has been used widely for the enrichment of mammary epithelial stem cells and breast cancer stem cells (CSCs). Epithelial-to-mese ...
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The association between chronic ...
Greater chronic disease burden may decrease quality of life (QOL) of breast cancer survivors. Our objective was to investigate the association betwe ...
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The chemokine receptor CCR4 pro ...
Increasing evidence has shown that chemokines and chemokine receptors are associated with tumor growth and metastasis. CCR4, an important chemokine ...
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Understanding of the immunologi ...
We have evaluated the phenotypic features of peripheral blood leukocytes as putative novel biomarkers with prognostic values to monitor canine mamma ...
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Tamoxifen metabolites as active ...
The mechanism of tamoxifen action in the treatment of breast cancer is believed to be via active metabolites that act as potent estrogen receptor an ...
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Excised and irradiated volumes ...
In early-stage breast cancer and DCIS patients, breast-conserving therapy is today’s standard of care. The purpose of this study was to evaluate the ...
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Glucocorticoid receptor activit ...
The purpose of this article is to determine the tumorigenic potential of estradiol treatment (E2) when combined with either progesterone (P4) or med ...
1.27 MB
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CG0006, a novel histone deacety ...
We previously reported that CG0006, a novel hydroxamate-based pan-histone deacetylase inhibitor (HDACI), suppresses the growth of human cancer cells ...
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Mitochondrial amplification sel ...
The metabolic phenotype of cancer, characterized by uncoupled mitochondrial respiration and increased mitochondrial oxidative stress, is an attracti ...
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Combined effects of MDM2 SNP309 ...
The MDM2 oncoprotein regulates the p53 pathway and, while functional polymorphisms of the MDM2 and p53 genes have been investigated for association ...
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Aberrant DNA methylation but no ...
CBP/p300-interacting transactivator with EDrich carboxy-terminal domain 4 (CITED4) inhibits HIF-1a transactivation by binding to CBP/p300. We hypoth ...
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