Simulation of Genes and Genomes Forward in Time
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Simulation of Genes and Genomes ...
The importance of simulation software in current and future evolutionary and genomic studies is just confirmed by the recent publication of several n ...
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DNA Polymerase ŋ , the Product ...
DNA polymerase (PolH) is the product of the xeroderma pigmentosum variant (XPV) gene and a well-characterized Y-family DNA polymerase for translesi ...
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Functional Genomics: New Insigh ...
Understanding the global gene expression profile of stem cells and their multilineage differentiation will be essential for their ultimate therapeuti ...
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Genomics for Weed Science
Numerous genomic-based studies have provided insight to the physiological and evolutionary processes involved in developmental and environmental proc ...
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Current Gene Expression Studies ...
Esophageal carcinoma is one of the deadliest cancers with highly aggressive potency, ranking as the sixth most common cancer among males and ninth mo ...
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Enjoy the Silence: The Story of ...
Cancer is a multi-step disease involving dynamic changes in the genome. However, studies on cancer genome so far have focused most heavily on protein ...
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Adenovirus E1B 55-Kilodalton Pr ...
Oncogenic transformation by adenovirus E1A and E1B-55K requires E1B-55K inhibition of p53 activity to prevent E1A-induced apoptosis. During viral inf ...
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The Development of Chromosome M ...
The technique of chromosome microdissection and microcloning has been developed for more than 20 years. As a bridge between cytogenetics and molecula ...
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Ascorbic Acid and Gene Expressi ...
Ascorbic acid (vitamin C, AA) has long been considered a food supplement necessary for life and for preventing scurvy. However, it has been reported ...
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Characteristics of Human and Mo ...
Characteristics of human and mouse orthologous gene sequences which have large G+C content variations were investigated in this study. The orthologou ...
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p53 induces distinct epigenetic ...
Background: The tumor suppressor protein p53 is a transcription factor that is mutated in many cancers. Regulation of gene expression by binding of w ...
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Dissecting microregulation of a ...
Background: The master regulator p53 tumor-suppressor protein through coordination of several downstream target genes and upstream transcription fact ...
2.92 MB
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Modulation of p53 activity by I ...
Background: In this work we present evidence that the p53 tumor suppressor protein and NF-êB transcription factors could be related through common de ...
1.67 MB
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P53 in human melanoma fails to ...
Background: Metastatic melanoma represents a major clinical problem. Its incidence continues to rise in western countries and there are currently no ...
2.16 MB
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Resistance of mitochondrial p53 ...
Background: Mutation of a tumor suppressor allele leaves the second as backup. Not necessarily so with p53. This homo-tetrameric transcription factor ...
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Cdk5 phosphorylates non-genotox ...
Background: p53 is the most studied tumor suppressor and its overexpression may or may not cause cell death depending upon the genetic background of ...
5.05 MB
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The antagonism between MCT-1 an ...
Background: MCT-1 oncoprotein accelerates p53 protein degradation via a proteosome pathway. Synergistic promotion of the xenograft tumorigenicity has ...
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Development of Calorie Restrict ...
Calorie restriction (CR) is the most robust intervention that decreases morbidity and mortality, and thereby increases the lifespan of many organisms ...
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Comparative Analyses of Plant T ...
Transcription factors (TFs) are proteinaceous complex, which bind to the promoter regions in the DNA and affect transcription initiation. Plant TFs c ...
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Incomplete Coverage of Candidat ...
Current genetic investigations are performed both on the basis of a rational and biologically based choice of candidate genes and through genome wide ...
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Telomeres and Thyroid Cancer
Telomeres are specialized structures at the ends of chromosomes, consisting of hundreds of repeated hexanucleotides (TTAGGG)n. Genetic integrity is p ...
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Role of NFAT5 in Inflammatory D ...
Nuclear factor of activated T cells 5 (NFAT5) is the most recently described member of the Rel family of transcription factors, including NF-..B and ...
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Application of Functional Genom ...
Plant cryobiology has primarily emerged from the classical fields of cryobiology and plant stress physiology. Cryopreservation tools are now availabl ...
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MicroRNA Gene Networks in Oncog ...
MicroRNAs are small non-coding RNAs that regulate gene expression at the transcriptional or posttranscriptional level. They are involved in cellular ...
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Ovarian Cancer Biomarkers: A Fo ...
Among the gynaecological malignancies, ovarian cancer is one of the neoplastic forms with the poorest prognosis and with the bad overall and disease- ...
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