Brain metastases exhibit gross deletions of the APC gen ...
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Brain metastases exhibit gross ...
Candidate genes involved in metastasis to the brain require investigation. In the present study, the adenomatous polyposis coli (APC) gene was analy ...
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Indeterminacy in the WHO classi ...
The WHO classifications of tumors are the global standards of tumor diagnosis. In spite of the detailed descriptions of the histopathological featur ...
142.88 KB
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Mediator of DNA damage checkpoi ...
The mediator of DNA damage checkpoint protein 1 (MDC1) regulates cell cycle checkpoints and recruits repair proteins to sites of double-stranded DNA ...
408.52 KB
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Functional implication of TRAIL ...
Recently, TRAIL function has been elucidated beyond its known classical role of mediating cellular homeostasis and immune surveillance against trans ...
599.91 KB
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DEAD box 1: a novel and indepen ...
Breast cancer is a heterogeneous disease characterized by diverse molecular signatures and a variable response to therapy. Clinical management of br ...
678.51 KB
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The TGF-b/Smad pathway induces ...
Transforming growth factor-b (TGF-b) has opposing roles in breast cancer progression by acting as a tumor suppressor in the initial phase, but stimu ...
640.46 KB
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Let-7 family miRNAs regulate es ...
In order to understand how microRNAs (miRNAs) regulate breast cancer tumorigenesis, a miRNA expression microarray screening was performed using RNA ...
815.83 KB
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An evaluation of the clinical s ...
Studies in mice have shown that thymicderived CD4? CD25? regulatory T cells (T reg; FOXP3? lymphocytes) inhibit an antitumour immune response. Addi ...
631.41 KB
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Benefits of early and prolonged ...
Response to fulvestrant and survival in postmenopausal hormone-sensitive advanced breast cancer was investigated within a non-randomized, In-Practic ...
237.60 KB
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Spectrum of BRCA1/2 point mutat ...
The distribution of BRCA1/2 germline mutations in breast/ovarian cancer (BC/OC) families varies among different populations. In the Chilean populati ...
دانلود 1
217.64 KB
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Occult breast carcinoma in brea ...
Breast reduction is a common surgical procedure performed by plastic and oncoplastic breast surgeons. The authors report on the incidence and manage ...
142.11 KB
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Association between patient rep ...
Neurotoxicity is a common side-effect during taxane therapy. The prevalence and severity of long-term neurotoxicity following therapy is unknown. Th ...
377.67 KB
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Effects on survival of menstrua ...
Adjuvant surgical oophorectomy is an effective and remarkably cost effective treatment for premenopausal women with hormone receptor positive operab ...
269.90 KB
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Evidence for biological effects ...
Metformin may reduce the incidence of breast cancer and enhance response to neoadjuvant chemotherapy in diabetic women. This trial examined the effe ...
442.41 KB
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Unfavourable pattern of metasta ...
Little is known about time trends in metastases in the patients treated in routine health care facilities without metastases at diagnosis (M0) and a ...
297.76 KB
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Evaluation of estrogen and prog ...
The objective of the present study was to compare the effects of tamoxifen and raloxifene in nonneoplastic breast epithelium. A randomized, double-b ...
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Risk of contralateral breast ca ...
Rare deleterious mutations in BRCA1 and BRCA2 are associated with an elevated risk of breast and ovarian cancer. Whether or not common variants in t ...
200.64 KB
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Vitamin D threshold to prevent ...
Aromatase inhibitor (AI)-associated arthralgia limits adherence to therapy in breast cancer. The pathophysiology may involve vitamin D status. We wi ...
250.60 KB
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The association between IGF1 CA ...
Recently, we read with interest the article by Huang et al. [1]. They performed a meta-analysis of nine case–control studies (5,641 cases and 10,471 ...
102.40 KB
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Associations between polymorphi ...
We read with great interest the article by Yang et al. which investigated the associations between tumor necrosis factor-a (TNF-a) polymorphisms an ...
229.85 KB
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FOXC1, a target of polycomb, in ...
Polycomb group (PcG) proteins have recently been shown related to cancer development. The PcG protein EZH2 is involved in progression of prostate an ...
614.71 KB
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Prognosis of metachronous contr ...
Studies comparing the prognosis after contralateral breast cancer (CBC) with that after unilateral breast cancer (UBC) shows conflicting results. We ...
282.69 KB
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Unliganded progesterone recepto ...
Whether the presence of steroid receptors in luminal breast cancers renders them resistant to taxanes remains uncertain. Here we assess the role of ...
730.96 KB
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First-line bevacizumab in combi ...
Despite extensive evaluation of first-line bevacizumab- containing therapy in randomized trials in locally recurrent/metastatic breast cancer (LR/mB ...
325.02 KB
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Effect of the overexpression of ...
Breast Cancer 2 gene (BRCA2) mutation carriers have a 45% chance of developing breast cancer and a 11% risk of developing ovarian cancer by the age ...
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