Hematopoietic Cell Regulation o ...
The last several decades have revealed numerous interactions between cells of the hematopoietic lineage and osteoblasts (OBs) of the mesenchymal lin ...
Diagnostic Thresholds in Osteop ...
Clinical trials are used to determine the efficacy and safety of a medication prior to approval for commercial use and to influence the prescribing ...
Bone Structural Components Regu ...
Tumors such as breast, lung, and prostate frequently metastasize to bone, where they can cause intractable pain and increase the risk of fracture in ...
Choosing a Treatment for Patien ...
The occurrence of a fragility fracture is an opportunity to recognize osteoporosis and begin treatment to reduce the risk of another fracture. Howev ...
Role of Altered Signal Transduc ...
Heterotopic ossification is a pathologic condition in which bone tissue is formed outside of the skeleton, within soft tissues of the body. The extr ...
Effects of Anti-osteoporosis Me ...
A number of fractures are complicated by impaired healing. This is prevalent in certain risk groups such as elderly, osteoporotics, postmenopausal w ...
Role of Endocrine and Paracrine ...
There appears to be no unique mechanically sensitive pathway by which changes in bone loading regulate bone mass and architecture to ensure adequate ...
The Role of Risk Communication ...
Risk assessment and communication of risk are essential components in the care of patients with osteoporosis. The risk of fracture in an untreated p ...
The Role of Bone Marrow and Vis ...
The protective effect of total fat mass on bone mineral density (BMD) has been challenged with studies showing no or negative association after adju ...
A Review of Osteoporosis Diagno ...
Fracture rates are known to vary by more than an order of magnitude worldwide; therefore, a single approach cannot be universally applied to all cou ...
FoxOs: Unifying Links Between O ...
Several mechanisms contribute to the decline of all physiologic functions during aging. As a consequence, disease incidence increases with age. Cent ...
Minor, Major, Low-Trauma, and H ...
Osteoporosis is a leading health problem worldwide due to the morbidity and mortality associated with fractures. However, a large number of fracture ...
Effects of Nutrition and Alcoho ...
It is well established that excessive consumption of high-fat diets results in obesity. However, the consequences of obesity on skeletal development ...
The Role of Falls in Fracture P ...
Close to 75% of hip and non-hip fractures occur among seniors age 65 years and older. Notably, the primary risk factor for a hip fracture is a fall, ...
A Central Role for Hypoxic Sign ...
Hypoxic signaling plays an essential role in maintaining oxygen homeostasis and cell survival. Hypoxia-inducible transcription factors HIF-1 and HIF ...
Osteoporosis: A Paradox in Anky ...
Ankylosing spondylitis is a chronic and severe inflammatory disease of the axial skeleton and the joints. Inflammation is associated with trabecular ...
Emerging Therapeutic Targets fo ...
Soft tissue sarcomas (STS) are malignancies of mesenchymal origin that represent approximately 1% of cancers in adults. Systematic research into the ...
Systematic Therapy for Unresect ...
Unresectable or metastatic disease occurs in 40% to 60% of soft-tissue sarcoma (STS) patients and portends a poor prognosis. For decades, doxorubici ...
Systemic Therapy Options for Un ...
Chordoma is an exceedingly rare tumor, marked by a slow growth rate. Surgery is the treatment of choice, but the most frequent sites of origin (spin ...
The Value of Data Collection wi ...
Collecting reliable and valid data is an increasing expectation within palliative care. Data remain the crux for demonstrating value and quality of ...
Non–Clear Cell Renal Cell Carci ...
Treatment for patients with metastatic non–clear cell renal cancer (RCC), who constitute 25% of all RCC patients, is largely undefined and tested al ...
Oral Dysplasia: Biomarkers, Tre ...
Dysplasia affecting the oral mucosa has a malignant potential. The options for treatment of oral dysplasia are limited. Surgery remains the mainstay ...
Can We Overcome the Effect of C ...
The Middle East has been experiencing an ongoing political conflict for the past several decades. This situation has been characterized by hostility ...
Penile Cancer: Epidemiology and ...
Penile cancer is an aggressive disease, with major psychological and social impact. The etiological factors are poor genital hygiene, the presence o ...
Endoscopic Resection of Sinonas ...
Malignant tumors of the sinonasal tract are rare, accounting for only 1% of all malignancies. Although they are associated with substantial histolog ...