Coupling Between Respiratory an ...
Enhanced sympathetic outflow to the heart and resistance vessels greatly contributes to the onset and maintenance of neurogenic hypertension. There ...
Metabolic Syndrome and Heart Fa ...
The constellation of obesity, hypertension, dyslipidemia, and insulin resistance—together referred to as metabolic syndrome (MetS)—is increasing in ...
Potential Dopamine-1 Receptor S ...
The role of dopamine receptors in blood pressure regulation is well established. Genetic ablation of both dopamine D1-like receptor subtypes (D1, D5 ...
Neural Mechanisms of Angiotensi ...
Chronically elevated plasma angiotensin II (AngII) causes a salt-sensitive form of hypertension that is associated with a differential pattern of pe ...
Nycthemeral Relationship betwee ...
Nycthemeral changes in renal function have been known for a long time, but our knowledge about the underlying mechanisms is still far from complete. ...
Mechanisms of Antiangiogenic-In ...
Antiangiogenic therapy has emerged as an important concept in the treatment of solid tumors. Vascular endothelial growth factor (VEGF) represents an ...
Mineralocorticoid Actions in th ...
Mineralocorticoid receptors (MR) and epithelial sodium channels (ENaC) in the brain mediate central aldosterone-induced sympathetic hyperactivity an ...
Knocking Out Angiotensin II in ...
Despite ongoing medical advances, cardiovascular disease continues to be a leading health concern. The renin-angiotensin system (RAS) plays an impor ...
Mineralocorticoid Receptor Bloc ...
Aldosterone antagonists have been highly successful in treating congestive heart failure and resistant hypertension. Until recently, therapies targe ...
Alcohol Consumption, Blood Pres ...
A synergistic effect of alcohol and hypertension has been suggested to increase the risk for stroke. However, the contribution of alcohol-induced hy ...
Cell Signaling of Angiotensin I ...
Angiotensin II (Ang II) is a pleiotropic hormone that influences the function of many cell types and regulates many organ systems. In the cardiovasc ...
Effects of Antihypertensive Tre ...
Essential hypertension is characterized by endothelial dysfunction due to reduced availability of nitric oxide (NO) secondary to increased generatio ...
Vascular Mechanisms in the Path ...
Stroke is one of the most devastating manifestations of two common diseases, atherosclerosis and hypertension. It represents the second leading caus ...
Estimation of Glomerular Filtra ...
Because of the high prevalence of chronic kidney disease, estimation of the glomerular filtration rate (GFR) is necessary to diagnose, stage, and fo ...
Mechanisms and Potential Therap ...
Preeclampsia is a pregnancy-induced hypertensive disorder found most commonly in nulliparous women. Recent research performed in animal models of th ...
Home Blood Pressure Monitoring: ...
Most management decisions for the diagnosis and treatment of hypertension are made using blood pressure (BP) measurements made in the clinic. Howeve ...
The Kidneys and Aldosterone/Min ...
Strong evidence supports the ability of the aldosterone/mineralocorticoid receptor (MR) system to dominate long-term blood pressure control. It is a ...
Vitamin D Therapy and Cardiovas ...
Vitamin D belongs to the family of nuclear steroid hormones, which has pleiotropic effects on several organ systems. Different vitamin D compounds h ...
Hypertension Due to Loss of Clo ...
In our consumer-oriented society, in which productivity requires around-the-clock activity and demanding shift work, the biologic system that regula ...
Aldosterone Synthase Inhibition ...
We report the first administration of an orally active aldosterone synthase inhibitor, LCI699, to 14 patients with primary aldosteronism. After a 2- ...
Does Blood Pressure Variability ...
Exactly how hypertension causes end organ damage and vascular events is poorly understood. Yet the concept that underlying “usual” blood pressure (B ...
Cardiovascular Complications in ...
Before effective antiretroviral treatment was introduced in children with HIV, cardiovascular complications were a major cause of morbidity and mort ...
Management of Fat Accumulation ...
The use of antiretroviral therapies has improved survival in people living with HIV to nearly normal rates. However, ongoing low-level HIV replicati ...
See-and-Treat Approaches to Cer ...
Cervical cancer remains the second commonest cancer among women worldwide, and more than 85% of the global burden of this disease occurs in the deve ...
Complex Decisions in Managing H ...
Both the World Health Organization and the United States Department of Health and Human Services have recently substantially revised perinatal HIV t ...