Association of the germline TP53 R72P and MDM2 SNP309 v ...
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Association of the germline TP5 ...
The tumor suppressor gene TP53 and its regulator MDM2 are both important players in the DNA-damage repair ‘‘TP53 response pathway’’. Common germline ...
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Routine pathologic parameters c ...
OncotypeDXTM is an RT-PCR-based assay used to predict chemotherapy benefit in patients with estrogen receptor (ER) positive breast cancers. We were ...
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Lack of any association between ...
Active metabolites of tamoxifen are formed mainly by the action of cytochrome P450 2D6 (CYP2D6). Since there are controversies regarding association ...
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Can we avoid axillary dissectio ...
There is considerable interest in foregoing axillary dissection (AD) when the sentinel node (SN) is positive in early breast cancer, particularly wh ...
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Genomic profiling of mitochondr ...
Oncocytic carcinomas are composed of mitochondrion- rich cells. Though recognised by the WHO classification as a histological special type of breast ...
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A HRM-based screening method de ...
The RAD51C gene has been recently proposed as a high-penetrance breast and ovarian cancer gene. However, early replication studies have failed to co ...
دانلود 1
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Associations of objectively ass ...
Physical activity reduces the risk of postmenopausal breast cancer through multiple inter-related biologic mechanisms; sedentary time may contribute ...
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Does the effect of weight lifti ...
The lymphedema diagnostic method used in descriptive or intervention studies may influence results found. The purposes of this work were to compare ...
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Gene expression profiling assig ...
CHEK2 1100delC is a moderate-risk cancer susceptibility allele that confers a high breast cancer risk in a polygenic setting. Gene expression profil ...
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MiR-28 regulates Nrf2 expressio ...
NF-E2-related factor 2 (Nrf2) is an important transcription factor involved in antioxidant response. Nrf2 binds antioxidant response elements (ARE) ...
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A diagnostic gene profile for m ...
Classification of breast cancer into molecular subtypes maybe important for the proper selection of therapy, as tumors with seemingly similar histop ...
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Responsiveness of adjacent duct ...
Adjacent ductal carcinoma in situ (DCIS) is found in approximately 45%of invasive ductal carcinomas (IDC) of the breast. Pure DCIS overexpresses HER ...
دانلود 2
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Mortality following bone metast ...
The aim of the study is to quantify the impact of bone metastasis and skeletal-related events (SREs) on mortality in older breast cancer patients. U ...
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Detection of circulating tumor ...
We read with great interest a recent article entitled ‘‘The prognostic role of circulating tumor cells (CTCs) detected by RT-PCR in breast cancer: a ...
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NQO1 expression correlates inve ...
NQO1 participates in cellular defense against oxidative stress and regulates apoptosis via p53- and NFjB-mediated pathways. We have previously found ...
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Serum CD44 levels and overall s ...
CD44 is an adhesion molecule involved in tumor cell invasion and metastasis. The function of CD44 in breast cancer is not understood completely, or ...
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Reproductive factors and histol ...
Evidence suggests that certain reproductive factors are more strongly associated with the incidence of lobular than of ductal breast cancer. The mec ...
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Targeted and intracellular trig ...
Limiting tumor invasion to the surrounding healthy tissues has proven to be clinically relevant for anticancer treatment options. We have demonstrat ...
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Outcome of triple-negative brea ...
More than 75% of breast cancers that develop in BRCA1 mutation carriers are triple-negative breast cancers (TNBC). The aim of this study was to comp ...
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Genomic analysis identifies uni ...
The ability to predict metastatic potential could be of great clinical importance, however, it is uncertain if predicting metastasis to specific vit ...
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SerpinB3, a new prognostic tool ...
It is unclear which patients with breast cancer benefit from anthracycline-based neoadjuvant chemotherapy and whether taxanes increase survival. Hsp ...
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Birth weight and other prenatal ...
Little is known about the role of birth weight and other prenatal factors in the etiology of breast cancer in Asian-Americans. We investigated the r ...
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Sentinel lymph node biopsy comp ...
Sentinel lymph node biopsy (SLNB) has been recommended as the standard performance for negative sentinel lymph node (SLN) patients without axillary ...
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Pathological complete response ...
Sequential doxorubicin/paclitaxel (AT) followed by CMF treatment was shown to be an active neoadjuvant chemotherapy regimen in the first European C ...
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Characterization of BRCA1 and B ...
Mutations in BRCA1 and BRCA2 predispose carriers to early onset breast and ovarian cancer. A common problem in clinical genetic testing is interpret ...
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