Triple negative breast cancer: unmet medical needs
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Triple negative breast cancer: ...
Triple negative breast cancer (TNBC) is an aggressive clinical phenotype characterized by lack of expression (or minimal expression) of estrogen rec ...
362.98 KB
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Ionizing radiation or mitomycin ...
BRCA1 and BRCA2 genes are essential in preserving the integrity of genome, and it is not unambiguously clear whether the heterozygosity status may a ...
299.63 KB
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Involvement of PKC delta (PKCd) ...
Doxorubicin is an anti-tumor antibiotic widely used in the management of cancer patients. Its main mechanism of action involves the generation of DN ...
459.14 KB
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Accumulation of mutations over ...
The occurrence of heteroplasmy and mixtures is technically challenging for the analysis of mitochondrial DNA. More than that, observed mutations nee ...
560.85 KB
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Large genomic rearrangements of ...
Germline mutations in BRCA1 and BRCA2 increase the risk for developing breast and ovarian cancer. Previously, the techniques available allowed only ...
582.68 KB
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The ErbB3 binding protein EBP1 ...
The ErbB2/3 heterodimer plays a critical role in breast cancer progression and in the development of endocrine resistance. EBP1, an ErbB3 binding pr ...
461.14 KB
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Immunoconjugated gold nanoshell ...
Trastuzumab is a FDA-approved drug that has shown clinical efficacy against HER2? breast cancers and is commonly used in combination with other chem ...
436.51 KB
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Effects of estrogen on the prop ...
There is increasing evidence that breast cancers contain tumor-initiating cells with stem cell properties. The importance of estrogen in the develop ...
819.91 KB
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Patterns and incidence of chrom ...
One of the hallmarks of human solid tumors is chromosomal instability (CIN). We studied global patterns as well as individual levels of CIN and dete ...
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Endoscopic breast surgery: wher ...
Endoscopic surgery has been extensively used for many surgical conditions and has gained acceptance as an alternative and less invasive approach to ...
1.60 MB
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Are we missing the mTOR target ...
Abnormalities in the PI3K/Akt/mTOR intracellular signalling pathway have been implicated in several forms of human cancer. The central component of ...
125.72 KB
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Gene expression analysis reveal ...
Male breast cancer (MBC) is a poorly characterized disease because of its rarity. Clinical management is based on results obtained from randomized t ...
384.83 KB
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miR-17-5p promotes human breast ...
MicroRNAs have been implicated in regulating diverse cellular pathways. Emerging evidence indicate that the miR-17-92 cluster may have a causal role ...
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RERG (Ras-like, oestrogen-regul ...
Global gene expression profiling studies have classified breast cancer into a number of distinct biological and molecular classes with clinical rele ...
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Soy isoflavones consumption and ...
Numbers of epidemiologic studies assessing soy consumption and risk of breast cancer have yielded inconsistent results. We aimed to examine the asso ...
295.93 KB
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Platelet-derived growth factor- ...
Platelet-derived growth factor-D (PDGF-D) has been linked with several human malignancies; however, its role in breast cancer progression is not kno ...
597.90 KB
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Loss of ICAM-1 signaling induce ...
Psoriasin (S100A7), a member of the S100 gene family, is highly expressed in high-grade comedo ductal carcinoma in situ (DCIS), with a higher risk o ...
766.49 KB
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‘‘Overcoming breast cancer drug ...
The mTOR pathway is pivotal not only in tumorigenesis but also in chemotherapy and hormonal drug sensitivity. It is clear that improvements in using ...
241.24 KB
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MIB1/Ki-67 labelling index can ...
Histological grade is recognized as one of the strongest prognostic factors in operable breast cancer (BC). Although grade 1 and grade 3 tumours are ...
473.23 KB
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RACK1 promotes breast carcinoma ...
We aimed to gain a mechanistic understanding of the role of RACK1 in breast carcinoma migration/ metastasis. Migration assays were conducted in brea ...
530.34 KB
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Safety of avoiding routine use ...
Physicians are moving away from routine axillary lymph node dissection (ALND) in clinically nodenegative breast cancer. We conducted a systemic revi ...
257.03 KB
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High RASSF1A promoter methylati ...
Previously, we reported that the accuracy of cytological diagnosis of breast lesions could be augmented through the quantitative assessment of DNA m ...
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256.86 KB
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Prognostic value of NDRG1 and S ...
An increasing number of studies have shown altered expression of secreted protein acidic and rich in cysteine (SPARC) and N-myc down-regulated gene ...
518.92 KB
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PKA-induced phosphorylation of ...
Phosphorylation of estrogen receptor a at serine 305 (ERaS305-P) by protein kinase A (PKA) or p21-activated kinase 1 (PAK1) has experimentally been ...
682.65 KB
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Anaplastic ependymoma simulatin ...
A case of anaplastic ependymoma of the cerebral hemisphere in which the histopathological features closely simulated those of glioblastoma is report ...
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