Hidden Markov Models and their Applications in Biologic ...
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Hidden Markov Models and their ...
Hidden Markov models (HMMs) have been extensively used in biological sequence analysis. In this paper, we give a tutorial review of HMMs and their ap ...
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The Protein Kinase Inhibitor Ba ...
Balanol, a fungal metabolite, is a potent ATP-competitive inhibitor of Protein Kinase C (PKC) and Protein Kinase A (PKA), important targets in oncolo ...
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High PIB Retention in Alzheimer ...
Background: New in vivo amyloid PET imaging tracers, such as 11C-PIB, provide possibilities to deeper understand the underlying pathological processe ...
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Assembly of the Asparagine- and ...
The proteins Ure2, Sup35 and Rnq1 from the baker’s yeast have infectious properties, termed prions, at the origin of heritable and transmissible phen ...
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Potential of DNMT and its Epige ...
Lung cancer, the leading cause of mortality in both men and women in the United States, is largely diagnosed at its advanced stages that there are no ...
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Metabotropic Glutamate Receptor ...
Multiple in vivo and in vitro studies show that excessive release of glutamate, and subsequent activation of ionotropic glutamate receptors (iGluRs) ...
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MicroRNA-21: From Cancer to Car ...
MicroRNA-21 (miR-21) expression is activated in multiple types of cancers, such as breast, liver, brain, prostate, myometrial cancers but also in car ...
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Phenotype Data: A Neglected Res ...
To a great extent, our phenotype is determined by our genetic material. Many genotypic modifications may ultimately become manifest in more or less p ...
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Mechanism of Action and Potenti ...
“Drinking several cups of green tea a day keeps the doctor away” is clearly an overstatement. However, extensive research has revealed that the predo ...
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A DNA vaccine against foot-and- ...
A plasmid DNA vaccine candidate (pCEIS) encoding two foot-and-mouth disease virus (FMDV) VP1 epitopes (amino acid residues 141–160 and 200–213) has b ...
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The Macrophage Stimulating Prot ...
Macrophage Stimulating Protein (MSP) is the only known ligand for the receptor tyrosine kinase Ron. The MSP/Ron pathway is involved in several import ...
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CL22 – a novel cationic peptide ...
Condensing peptide–DNA complexes have great potential as nonviral agents for gene delivery. To date, however, such complexes have given transfection ...
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Genome Annotation in Plants and ...
In this era of whole genome sequencing, reliable genome annotations (identification of functional regions) are the cornerstones for many subsequent a ...
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Potential Uses of MicroRNA in L ...
Lung cancer is the leading cause of death from cancer in the world. Although the molecular network of lung carcinogenesis has been partly known at th ...
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The Biology of TRAIL and the Ro ...
TNF-related apoptosis inducing ligand (TRAIL) is a key mediator of the innate immune response to infection. While TRAIL-mediated apoptosis plays an e ...
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Pharmacological Characteristics ...
K201 is a 1,4-benzothiazepine derivative that is a promising new drug with a strong cardioprotective effect. We initially discovered K201 as an effec ...
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Signal Processing for Metagenom ...
Traditionally, studies in microbial genomics have focused on single-genomes from cultured species, thereby limiting their focus to the small percenta ...
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Runx1/AML1 is a Guardian of Hem ...
An oncogenic stimulus in a cell primarily results in hyperproliferation. However, uncontrolled cell proliferation is sensed by the cell and triggers ...
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CENPA a Genomic Marker for Cent ...
Inheritance of genetic material requires that chromosomes segregate faithfully during cell division. Failure in this process can drive to aneuploidy ...
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Inhibition of Protein Kinase c- ...
c-Src is a proto-oncogene involved in the genesis of and invasion by many cancers. This non-receptor tyrosine kinase also plays a crucial role in bon ...
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Anti-Apoptotic Genes in the Sur ...
Macrophages are cells of the immune system that protect organisms against invading pathogens by fulfilling critical roles in innate and adaptive immu ...
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Treatment with Imiquimod enhanc ...
Background: There is an urgent need to develop new innovative therapies for the control of advanced cancer. The combination of antigen-specific immun ...
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Towards Retinoid Therapy for Al ...
Alzheimer’s disease(AD) is associated with a variety of pathophysiological features, including amyloid plaques, inflammation, immunological changes, ...
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Targeting RSK: An Overview of S ...
Ribosomal S6 kinase (RSK) is a family of serine/threonine kinases that has been identified as a promising anti-cancer target. While a number of prote ...
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Nutritional Modulation of Termi ...
Findings with experimental rodent models reveal that exposures to dietary factors during the in utero and pubertal periods when the mammary gland is ...
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