Dihydrofolate Reductase Gene Variations in Susceptibili ...
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Genetics in Osteoarthritis
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Dihydrofolate Reductase Gene Va ...
Dihydrofolate reductase (DHFR) catalyzes the reduction of dihydrofolate to tetrahydrofolate (THF). THF is needed for the action of folate-dependent e ...
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Array-Based Approaches for the ...
Carcinogenesis involves the inactivation or inhibition of genes that function as tumor suppressors. Deletions, mutations, or epigenetic silencing of ...
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Gene Expression Profiling as a ...
The identification of quantitative trait loci, QTL, in arthritis animal models is a straight forward process. However, to identify the underlying gen ...
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The Double Identity of WSX-1 (I ...
Two heterodimeric cytokines, IL-23 and IL-27, were recently identified, which have structural and functional homology to IL-12. IL-27, composed of p2 ...
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Platelet count and neonatal sep ...
Introduction: Sepsis is a common complication in the neonatal intensive care unit. It is most common in the smallest and most premature infants in who ...
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Obstructive Sleep Apnea Syndrom ...
Obstructive sleep apnea syndrome (OSAS) is a complex chronic clinical syndrome, characterized by snoring, periodic apnea, hypoxemia during sleep, and ...
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Genomic Instability and Carcino ...
Cancers arise as a result of stepwise accumulation of mutations which may occur at the nucleotide level and/or the gross chromosomal level. Many canc ...
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Internet Resources for Gene Exp ...
The number of online databases and web-tools for gene expression analysis in Arabidopsis thaliana has increased tremendously during the last years. T ...
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Development of Calorie Restrict ...
Calorie restriction (CR) is the most robust intervention that decreases morbidity and mortality, and thereby increases the lifespan of many organisms ...
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The p53 Pathway Encounters the ...
The p53 protein is a transcription factor that regulates multiple cellular processes in human and other high eukaryotes including cell proliferation, ...
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Lipid-Based Membrane Microdomai ...
The immune system is able to mount an immune response against antigens present in the body at very low concentrations and, at the same time, to discr ...
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Mitochondrial Signal Transducti ...
Engagement of T cell receptors by antigen-presenting cells or stimulation by cytokines determine whether the cell will become activated, anergic or d ...
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Lung Cancer: Are we up to the C ...
Lung cancer is the leading cause of cancer deaths worldwide among both men and women, with more than 1 million deaths annually. Non–small cell lung c ...
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Genetics in Osteoarthritis
Osteoarthritis is a degenerative articular disease with complex pathogeny because diverse factors interact causing a process of deterioration of the ...
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Simulation of Genomes: A Review
There is an increasing role of population genetics in human genetic research linking empirical observations with hypotheses about sequence variation ...
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Bacterial meningitis: a new ris ...
BACKGROUND: The purpose of this study is to discuss a possible new risk factor for the bacterial meningitis. METHODS: Cerebrospinal fluid collected f ...
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Cancer Metastasis as Disrupted ...
Cancer metastasis is a complex processes, associated with the invasion to tissues with extensive degradation of the surrounding normal components, pe ...
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Haplotypes in SLC24A5 Gene as A ...
Ancestry informative markers (AIMs) are human polymorphisms that exhibit substantially allele frequency differences among populations. These markers ...
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Exosomes: Specific Intercellula ...
The term “exosome” was coined in 1981 (Trams et al, Biochim Biophys Acta, 1981, 645:63) when the presence of “exfoliated membrane vesicles with 5’-nu ...
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Meaningful Interpretation of Su ...
In living cell or its nucleus, the motions of molecules are complicated due to the large crowding and expected heterogeneity of the intracellular env ...
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Structure-Function Relationship ...
This review focuses on the structure and mode-of-action of non-lanthionine-containing peptide bacteriocins produced by Gram-positive bacteria. These ...
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Abnormal Choline Phospholipid M ...
Elevated contents of choline phospholipid metabolites are typically detected by nuclear magnetic resonance spectroscopy (MRS) in human and animal tum ...
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Role of TARC/CCL17 and CTACK/CC ...
TARC/CCL17 is designated as a Th2 type chemokine since it binds to CCR4. CTACK/CCL27 is a ligand for CCR10 and is selectively expressed in skin. Atop ...
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Metabolite Quantification in Tu ...
Magnetic resonance spectroscopy (MRS) allows non invasive detection of tissue metabolism. Absolute or relative quantification of metabolites and chem ...
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Cellular and Molecular Regulati ...
The milieu of inflammatory cells and inflammatory mediators is crucially involved in the genesis, persistence and severity of pain following trauma, ...
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