Agonists and antagonists of GnRH-I and -II reduce metas ...
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Agonists and antagonists of GnR ...
Metastasis to bone is a frequent problem of advanced breast cancer. Particularly breast cancers, which do not express estrogen and progesterone rece ...
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Combination of the proliferatio ...
Global gene expression profiles, consisting mainly of genes associated with proliferation, have been shown to subdivide histological grade 2 breast ...
291.70 KB
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Oncological and cosmetic outcom ...
An inappropriate skin incision on the breast reduces the cosmetic benefit of breast-conserving surgery (BCS). To improve the cosmetic outcome, we ha ...
451.70 KB
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TP53 genomics predict higher cl ...
To determine rates of pathologic complete response (pCR) and near-complete response (npCR) in operable early-stage breast cancer using neoadjuvant ...
406.96 KB
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Neoadjuvant chemotherapy in ER+ ...
A pathological complete remission (pCR) is rarely achieved by neoadjuvant chemotherapy in estrogen receptor-positive (ER?) HER2-negative (HER2-) tum ...
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Mutational characterization of ...
Understanding how cancer genes are mutated in individual tumors is an important issue with potential clinical and therapeutic impact. This is especi ...
286.95 KB
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Estrogen and insulin-like growt ...
Although estrogen receptor alpha (ERa) and insulin-like growth factor (IGF) signaling are important for normal mammary development and breast cancer ...
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Insulin-like growth factor rece ...
Insulin-like growth factor-1 receptor (IGF-1R) is expressed in normal and malignant breast tissue and has been implicated in cell survival and resis ...
336.36 KB
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Unmet supportive care needs: a ...
The comparison of psychosocial needs across different cultural settings can identify cultural and service impacts on psychosocial outcomes. We compa ...
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Bone metastasis in a novel brea ...
In practice, investigations for bone metastasis of breast cancer rely heavily on models in vivo. Lacking of such ideal model makes it difficult to s ...
561.20 KB
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Mutation analysis of the SLX4/F ...
SLX4 coordinates three structure-specific endonucleases in the DNA damage response. One subtype of Fanconi anaemia, FA-P, has recently been attribut ...
349.93 KB
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Inhibition of aldehyde dehydrog ...
The majority of breast cancer deaths are because of ineffective treatment of metastatic disease. We previously identified a subpopulation of cells i ...
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The association between IGF1 CA ...
Recently, we read with interest the article by Huang et al. [1]. They performed a meta-analysis of nine case–control studies (5,641 cases and 10,471 ...
102.40 KB
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Genome-wide copy number alterat ...
Genomic copy number alterations (CNA) are common in breast cancer. Identifying characteristic CNAs associated with specific breast cancer subtypes i ...
دانلود 1
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Identification and characteriza ...
BAF57 is a core subunit present in all mammalian SWI/SNF ATP-dependent chromatin remodeling complexes, which regulates important biological processe ...
534.23 KB
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Germline mutational analysis of ...
The past two decades have seen steady progress in the field of breast cancer genetics as we continually increase our understanding of how tumorigene ...
174.96 KB
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High estrogen receptor expressi ...
One of the most controversial questions in early breast cancer treatment is the need of chemotherapy in patients with estrogen receptor positive dis ...
404.08 KB
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Prediagnostic plasma enterolact ...
Experimental and epidemiological studies have suggested that the phytoestrogen enterolactone is associated to biological mechanisms that may have po ...
283.07 KB
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PARP-1 expression in breast can ...
Despite ongoing trials of PARP inhibitors in the treatment of breast cancer (BC), the extent of poly (ADP-ribose)polymerase-1 (PARP-1) protein expre ...
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The impact of contralateral mas ...
Among women with breast cancer and a BRCA1 or BRCA2 mutation, the lifetime risk of breast cancer may be as high as 40%. Many physicians recommend p ...
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Replication of genome-wide disc ...
Genome-wide association studies (GWAS) have identified associations with robust statistical support for influencing breast cancer susceptibility. Mo ...
224.02 KB
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A nationwide analysis of incide ...
In this study, we describe the incidence, treatment, and outcome of breast cancer (BC) during the period 1994–2003 in the South-American country of ...
264.32 KB
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BRIP1, PALB2, and RAD51C mutati ...
Mutations in the recognized breast cancer susceptibility genes BRCA1, BRCA2, TP53, ATM, and CHEK2 account for approximately 20% of hereditary breast ...
234.73 KB
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Germline ATM mutational analysi ...
Biallelic inactivation of ATM gene causes the rare autosomal recessive disorder Ataxia-telangiectasia (A-T). Female relatives of A-T patients have a ...
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Race and age disparities in rec ...
To evaluate differences in use of sentinel lymph node biopsy (SLNB) by age and race in Medicare recipients with early-stage breast cancer, we examin ...
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