Targeting RSK: An Overview of Small Molecule Inhibitors
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Targeting RSK: An Overview of S ...
Ribosomal S6 kinase (RSK) is a family of serine/threonine kinases that has been identified as a promising anti-cancer target. While a number of prote ...
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Inhibition of Protein Kinase c- ...
c-Src is a proto-oncogene involved in the genesis of and invasion by many cancers. This non-receptor tyrosine kinase also plays a crucial role in bon ...
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Runx1/AML1 is a Guardian of Hem ...
An oncogenic stimulus in a cell primarily results in hyperproliferation. However, uncontrolled cell proliferation is sensed by the cell and triggers ...
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Genome Annotation in Plants and ...
In this era of whole genome sequencing, reliable genome annotations (identification of functional regions) are the cornerstones for many subsequent a ...
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Metabotropic Glutamate Receptor ...
Multiple in vivo and in vitro studies show that excessive release of glutamate, and subsequent activation of ionotropic glutamate receptors (iGluRs) ...
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Assembly of the Asparagine- and ...
The proteins Ure2, Sup35 and Rnq1 from the baker’s yeast have infectious properties, termed prions, at the origin of heritable and transmissible phen ...
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The Protein Kinase Inhibitor Ba ...
Balanol, a fungal metabolite, is a potent ATP-competitive inhibitor of Protein Kinase C (PKC) and Protein Kinase A (PKA), important targets in oncolo ...
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Development of Non-Nucleoside R ...
The NNRTIs play an important role in the present therapy against HIV/AIDS. This review discusses the basic principles in the development of NNRTIs fo ...
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Role of Mismatch Repair and MGM ...
Tumor resistance to cytotoxic chemotherapy drugs and their toxicity to normal cells are major clinical obstacles to anticancer therapy effectiveness. ...
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Influence of Enzyme-Inducing An ...
Background: Imatinib mesylate is used in combination with hydroxyurea (HU) in ongoing clinical phase II studies in recurrent glioblastoma multiforme ...
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Rapid Screening of Toxigenic Vi ...
The ability to sensitively detect Vibrio cholera with PCR-ELISA method represents a considerable advancement over alternative more time-consuming met ...
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Identification of Salmonella en ...
Salmonella enterica serovar Typhi is a human pathogenic microorganism with a very complex infective cycle, involving the transit of bacteria across d ...
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Genome Annotation in Plants and ...
In this era of whole genome sequencing, reliable genome annotations (identification of functional regions) are the cornerstones for many subsequent a ...
373.84 KB
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INVESTIGATION OF DEEP STERNAL W ...
Objective: To investigate factors that predict sternal wound complications in patients after coronary artery bypass grafting (CABG) because predictio ...
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Midkine is a NF-κB-inducible ge ...
Background: Midkine is a heparin-binding growth factor that is over-expressed in various human cancers and plays important roles in cell transformati ...
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Computational Approaches for Pr ...
A central focus of cancer genetics is the study of mutations that are causally implicated in tumorigenesis. Although missense variants are commonly i ...
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The Absence of Ser389 Phosphory ...
Phosphorylation is important in p53-mediated DNA damage responses. After UV irradiation, p53 is phosphorylated specifically at murine residue Ser389. ...
1.99 MB
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Resistance of mitochondrial p53 ...
Background: Mutation of a tumor suppressor allele leaves the second as backup. Not necessarily so with p53. This homo-tetrameric transcription factor ...
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Dissecting microregulation of a ...
Background: The master regulator p53 tumor-suppressor protein through coordination of several downstream target genes and upstream transcription fact ...
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p53 induces distinct epigenetic ...
Background: The tumor suppressor protein p53 is a transcription factor that is mutated in many cancers. Regulation of gene expression by binding of w ...
1.49 MB
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Gene transfer: the challenge of ...
Gene therapy is expected to have a major impact on human healthcare in the future. However, precise regulation of therapeutic gene expression in viv ...
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Nutritional Deficiencies in Mor ...
It is a common belief that clinical vitamin or mineral deficiencies are rare in Western countries because of the low-cost and unlimited diversity of ...
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Fighting spinal cord complicati ...
Paraplegia or paraparesis after otherwise successful thoracic or thoracoabdominal aortic reconstruction is a devastating complication for both patie ...
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An overview of current biomater ...
Today an increasing number of patients seek aesthetic improvement through minimally invasive procedures, and interest in soft tissue augmentation an ...
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Acute urinary retention in preg ...
Female acute urinary retention in pregnancy is a relatively uncommon condition. Its relatively low incidence and little published evidence base lead ...
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