Updates on Rectal Cancer
Drugs on the Horizon for Colore ...
Colorectal cancer (CRC) is the second leading cause of cancer death in the United States, and research advances over the past 20 years have allowed ...
NOTCH Signaling and ATOH1 in Co ...
The Notch receptor signaling pathway regulates expression of the basic helix-loop-helix transcription factor ATOH1 (Math1/Hath1) to determine cell f ...
Updates on Rectal Cancer
In the last few decades there has been a shift in the paradigm of rectal cancer treatment. Surgery, historically the only weapon against rectal mali ...
Genetic Evaluation of Polyposis
There is substantial ongoing work in elucidating the genetics of colorectal cancer (CRC). In this article, the state of the art and clinical applica ...
Colorectal Cancer Stem Cells: B ...
The hypothesis that cancer is driven by a subpopulation of tumor-initiating or cancer stem cells (CSC), defined by their selective ability for exten ...
Why Cetuximab is Not Active in ...
Cetuximab—a humanized monoclonal antibody targeting EGFR—can extend progression-free survival in patients with metastatic colorectal cancer. EGFR ne ...
Technical Advances in Getting t ...
Clinical demand for colonoscopy has increased with the introduction of colorectal cancer screening worldwide. The goal is a complete, comfortable, a ...
Molecular Prognostic and Predic ...
In parallel with our growing understanding of the molecular pathways underlying colorectal neoplasia, significant advances have been made in the tre ...
Should We Perform a New Adjuvan ...
Colorectal cancer is a major cause of cancer-related morbidity and mortality. Complete surgical resection continues to be the mainstay of treatment, ...
Optical Enhancements in Diagnos ...
The influx of new endoscopic technologies produces continuous evolution in diagnostic modalities, especially in colorectal cancer screening. New tec ...
Mechanisms Regulating Microtubu ...
Colorectal cancer (CRC) results from the progressive accumulation of both genetic and epigenetic alterations that lead to the transformation of norm ...
Biological Markers in Patients ...
Colorectal cancer is one of the most common malignancies in the Westernized world. Particularly in the setting of metastatic disease, advances in th ...
Prevention by Aspirin of Colore ...
In a randomized controlled trial (RCT), 272 patients were assigned to lysine acetylsalicylate 160 mg/day (n=73) or 300 mg/day (n=67) or placebo (n=1 ...
Who Benefits from Portal Vein E ...
Preoperative portal vein embolization (PVE) is used to increase the volume and function of the liver that will remain after major hepatectomy (the f ...
Reduced Chemotherapy Duration: ...
Over the past three decades, survival outcomes of high-risk stage II and stage III colon cancer have improved with the use of adjuvant chemotherapy. ...
Hyperplastic Polyps: Are They C ...
Until recently, all serrated polyps were classified simply as hyperplastic polyps and were thought to represent benign lesions with no progression t ...
Laparoscopic Hepatectomy for Co ...
Colorectal metastases represent the most common hepatic malignancy, and experience has shown that surgical resection may offer long-term cure in sel ...
Is There a Future for Bevacizum ...
Fluoropyrimidine-based regimens have become the standard adjuvant treatment for stage III colorectal cancer (CRC). Despite the superior outcomes wit ...
Serrated Pathway to Colorectal ...
Serrated polyps of the colorectum are formed by a spectrum of lesions that share a unique histological feature- the presence of sawtooth-shaped cryp ...
Who Should Receive Neoadjuvant ...
The role for neoadjuvant chemotherapy in patients with colorectal cancer liver metastases has expanded over the last 10 years. Evolution of various ...
A New Era of Fibers in the Prev ...
Several studies have indicated a role for diet in the etiology of colorectal cancer. Dietary fibers are a heterogeneous group of compounds consistin ...
Fecal Tests: From Blood to Mole ...
Detection of molecular markers for colorectal neoplasia in feces has the potential to improve performance of simple noninvasive screening tests for ...
Adjuvant Therapy After Liver Re ...
Synchronous or metachronous liver metastases of colorectal origin (colorectal liver metastases, CLM), although being the expression of systemic dise ...
Decreased-Purgation CT Colonogr ...
In the setting of CT colonography (CTC), decreasing bowel preparation measures may help to optimize colorectal cancer screening compliance without ...
Liver Resection for Colorectal ...
Liver resection is the only cure-oriented strategy for colorectal liver metastases, even in elderly patients. In the literature, there are no signif ...