Does Blood Pressure Variability Modulate Cardiovascular ...
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Does Blood Pressure Variability ...
Exactly how hypertension causes end organ damage and vascular events is poorly understood. Yet the concept that underlying “usual” blood pressure (B ...
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Aldosterone Synthase Inhibition ...
We report the first administration of an orally active aldosterone synthase inhibitor, LCI699, to 14 patients with primary aldosteronism. After a 2- ...
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Hypertension Due to Loss of Clo ...
In our consumer-oriented society, in which productivity requires around-the-clock activity and demanding shift work, the biologic system that regula ...
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Obesity and the Kidney
Background and objectives Obesity-related glomerulopathy (ORG) is an increasing cause of end-stage renal disease, but evidence concerning the effect ...
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Vitamin D Therapy and Cardiovas ...
Vitamin D belongs to the family of nuclear steroid hormones, which has pleiotropic effects on several organ systems. Different vitamin D compounds h ...
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The Kidneys and Aldosterone/Min ...
Strong evidence supports the ability of the aldosterone/mineralocorticoid receptor (MR) system to dominate long-term blood pressure control. It is a ...
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Endogenous Ouabain: A Link Betw ...
The sodium pump, an ancestral enzyme with conserved ability to bind ouabain, plays a key role in salt conservation and is regulated by aldosterone a ...
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Home Blood Pressure Monitoring: ...
Most management decisions for the diagnosis and treatment of hypertension are made using blood pressure (BP) measurements made in the clinic. Howeve ...
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Mechanisms and Potential Therap ...
Preeclampsia is a pregnancy-induced hypertensive disorder found most commonly in nulliparous women. Recent research performed in animal models of th ...
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Estimation of Glomerular Filtra ...
Because of the high prevalence of chronic kidney disease, estimation of the glomerular filtration rate (GFR) is necessary to diagnose, stage, and fo ...
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Vascular Mechanisms in the Path ...
Stroke is one of the most devastating manifestations of two common diseases, atherosclerosis and hypertension. It represents the second leading caus ...
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Epigenetics and Hypertension
Epigenetics refers to mechanisms for environment– gene interactions (mainly by methylation of DNA and modification of histones) that do not alter th ...
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Effects of Antihypertensive Tre ...
Essential hypertension is characterized by endothelial dysfunction due to reduced availability of nitric oxide (NO) secondary to increased generatio ...
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Cell Signaling of Angiotensin I ...
Angiotensin II (Ang II) is a pleiotropic hormone that influences the function of many cell types and regulates many organ systems. In the cardiovasc ...
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Alcohol Consumption, Blood Pres ...
A synergistic effect of alcohol and hypertension has been suggested to increase the risk for stroke. However, the contribution of alcohol-induced hy ...
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Mineralocorticoid Receptor Bloc ...
Aldosterone antagonists have been highly successful in treating congestive heart failure and resistant hypertension. Until recently, therapies targe ...
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Dietary Fructose and Hypertensi ...
The association between fructose and increased blood pressure is still incompletely defined, because experimental studies have produced dissimilar c ...
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Knocking Out Angiotensin II in ...
Despite ongoing medical advances, cardiovascular disease continues to be a leading health concern. The renin-angiotensin system (RAS) plays an impor ...
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Mineralocorticoid Actions in th ...
Mineralocorticoid receptors (MR) and epithelial sodium channels (ENaC) in the brain mediate central aldosterone-induced sympathetic hyperactivity an ...
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Mechanisms of Antiangiogenic-In ...
Antiangiogenic therapy has emerged as an important concept in the treatment of solid tumors. Vascular endothelial growth factor (VEGF) represents an ...
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Catecholamine Storage Vesicles: ...
Hypertension is a complex trait with deranged autonomic control of the circulation. The sympathoadrenal system exerts minute-to-minute control over ...
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Nycthemeral Relationship betwee ...
Nycthemeral changes in renal function have been known for a long time, but our knowledge about the underlying mechanisms is still far from complete. ...
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Neural Mechanisms of Angiotensi ...
Chronically elevated plasma angiotensin II (AngII) causes a salt-sensitive form of hypertension that is associated with a differential pattern of pe ...
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Potential Dopamine-1 Receptor S ...
The role of dopamine receptors in blood pressure regulation is well established. Genetic ablation of both dopamine D1-like receptor subtypes (D1, D5 ...
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Genetics of Hypertension and Ca ...
Blood pressure (BP), hypertension (HT) and cardiovascular disease (CVD) are common complex phenotypes, which are affected by multiple genetic and en ...
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