Point-of-Care Testing
IL28B Polymorphisms and Treatme ...
Recently, single-nucleotide polymorphisms near the IL28B gene have been identified as important in predicting treatment response and spontaneous cle ...
Current Antiviral Therapy of Ch ...
The treatment of chronic hepatitis B is in constant evolution. Interferon, the first agent licensed for chronic hepatitis B treatment, has been supe ...
Vitamin D in HIV-Infected Patie ...
Observational studies have noted very high rates of low 25(OH)D (vitamin D) levels in both the general and HIV-infected populations. In HIV-infected ...
Cancer Screening in Patients In ...
Non–AIDS-defining cancers are a rising health concern among HIV-infected patients. Cancer screening is now an important component of health maintena ...
Revisiting Immune Exhaustion Du ...
Chronic immune activation is a hallmark of HIV infection, yet the underlying triggers of immune activation remain unclear. Persistent antigenic stim ...
Gene Therapy Strategies: Can We ...
Despite the tremendous advances in antiretroviral combination therapy over the last decade, eradication of HIV from the infected organism is still ...
HIV/HCV Co-infection: Pathogene ...
World-wide, hepatitis C virus (HCV) accounts for approximately 130 million chronic infections, with an overall 3% prevalence. Four to 5 million pers ...
Improving the Diagnosis of Tube ...
The diagnosis of latent and active tuberculosis in the HIV-positive population is challenged by diminished sensitivity of conventional tests, atypic ...
Antiretroviral Therapy: A Key C ...
Transmission of HIV is critically dependent on the level of HIV viral load within blood and genital secretions. Antiretroviral therapy results in su ...
Renal Issues in HIV Infection
Kidney disease remains a prominent complication of HIV disease, despite beneficial effects of antiretroviral therapy on the natural history of HIV-a ...
Alterations of the B-Cell Respo ...
While the hallmark of HIV-1 infection is the progressive depletion of CD4+ T cells, extensive B-cell dysfunction ensues that impairs the quality of ...
Preexposure Prophylaxis for HIV ...
Reducing the incidence of HIV remains one of our greatest public health challenges. However, there is growing optimism that preexposure prophylaxis ...
Topical Prophylaxis for HIV Pre ...
Strategies to protect against sexual transmission of HIV include the development of products formulated for topical application, which limit the tox ...
Adding Fuel to the Fire: Alcoho ...
Alcohol consumption adds fuel to the HIV epidemic in sub-Saharan Africa (SSA). SSA has the highest prevalence of HIV infection and heavy episodic dr ...
Point-of-Care Testing
The availability of rapid, point-of-care (POC) tests has significantly expanded the capacity of both developed and resource-constrained countries (R ...
Noninvasive Assessment of HIV-r ...
Highly active antiretroviral therapy has led to significant declines in infection-related mortality in HIVinfected patients. Cardiovascular disease ...
Influenza and HIV: Lessons from ...
Influenza is a common respiratory disease in adults, including those infected with HIV. In the spring of 2009, a pandemic influenza A (H1N1) virus ( ...
The Search for Host Genetic Fac ...
Though pursuit of host genetic factors that influence the pathogenesis of HIV began over two decades ago, progress has been slow. Initial genome-lev ...
Complex Decisions in Managing H ...
Both the World Health Organization and the United States Department of Health and Human Services have recently substantially revised perinatal HIV t ...
See-and-Treat Approaches to Cer ...
Cervical cancer remains the second commonest cancer among women worldwide, and more than 85% of the global burden of this disease occurs in the deve ...
Coreceptors and HIV-1 Pathogene ...
The major HIV-1 coreceptors, CCR5 and CXCR4, mediate virus entry into CD4+ cells and are therefore a critical component of the HIV-1 life cycle. Al ...
Management of Fat Accumulation ...
The use of antiretroviral therapies has improved survival in people living with HIV to nearly normal rates. However, ongoing low-level HIV replicati ...
Pathogenesis of HIV in the Cent ...
HIV can infect the brain and impair central nervous system (CNS) function. Combination antiretroviral therapy (cART) has not eradicated CNS complica ...
Cardiovascular Complications in ...
Before effective antiretroviral treatment was introduced in children with HIV, cardiovascular complications were a major cause of morbidity and mort ...
Combination HIV Prevention: Sig ...
No single HIV prevention strategy will be sufficient to control the HIV pandemic. However, a growing number of interventions have shown promise in p ...