Reduced Chemotherapy Duration: A Good Idea?
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Updates on Rectal Cancer
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Reduced Chemotherapy Duration: ...
Over the past three decades, survival outcomes of high-risk stage II and stage III colon cancer have improved with the use of adjuvant chemotherapy. ...
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Who Benefits from Portal Vein E ...
Preoperative portal vein embolization (PVE) is used to increase the volume and function of the liver that will remain after major hepatectomy (the f ...
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Biological Markers in Patients ...
Colorectal cancer is one of the most common malignancies in the Westernized world. Particularly in the setting of metastatic disease, advances in th ...
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Mechanisms Regulating Microtubu ...
Colorectal cancer (CRC) results from the progressive accumulation of both genetic and epigenetic alterations that lead to the transformation of norm ...
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Optical Enhancements in Diagnos ...
The influx of new endoscopic technologies produces continuous evolution in diagnostic modalities, especially in colorectal cancer screening. New tec ...
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Should We Perform a New Adjuvan ...
Colorectal cancer is a major cause of cancer-related morbidity and mortality. Complete surgical resection continues to be the mainstay of treatment, ...
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Molecular Prognostic and Predic ...
In parallel with our growing understanding of the molecular pathways underlying colorectal neoplasia, significant advances have been made in the tre ...
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Why Cetuximab is Not Active in ...
Cetuximab—a humanized monoclonal antibody targeting EGFR—can extend progression-free survival in patients with metastatic colorectal cancer. EGFR ne ...
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Colorectal Cancer Stem Cells: B ...
The hypothesis that cancer is driven by a subpopulation of tumor-initiating or cancer stem cells (CSC), defined by their selective ability for exten ...
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Updates on Rectal Cancer
In the last few decades there has been a shift in the paradigm of rectal cancer treatment. Surgery, historically the only weapon against rectal mali ...
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NOTCH Signaling and ATOH1 in Co ...
The Notch receptor signaling pathway regulates expression of the basic helix-loop-helix transcription factor ATOH1 (Math1/Hath1) to determine cell f ...
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Drugs on the Horizon for Colore ...
Colorectal cancer (CRC) is the second leading cause of cancer death in the United States, and research advances over the past 20 years have allowed ...
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An Update on the Biology of RAS ...
Deaths caused by colorectal cancer (CRC) are among the leading causes of cancer-related death in the United States and around the world. Approximate ...
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Should There Be a Different Car ...
The concept of a polypill for cardiovascular disease prevention has attracted widespread attention since Wald and Law’s seminal paper in 2003. The a ...
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Workplace Interventions to Redu ...
The worksite is ideal for implementing interventions to reduce obesity and cardiometabolic risk factors. Although worksite health promotion is not n ...
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Alcohol and Cardiovascular Risk ...
Understanding the many health effects of even moderate alcohol use in women is not an easy task for clinicians. Moderate intake has been consistentl ...
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The Global Burden of Cardiovasc ...
Some consider the measurements of arterial elasticity and flow-mediated dilation to be an indirect “biomarker” of endothelial dysfunction. As such, ...
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Case Series of Takotsubo Cardio ...
Takotsubo cardiomyopathy, also known as apical ballooning syndrome or stress-induced cardiomyopathy, is characterized by reversible left ventricular ...
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Salt Restriction and Challenges ...
This article reviews the best evidence currently available worldwide on the causal relationship between salt intake and blood pressure and its relat ...
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Genetic Predictors of Exercise ...
Both observational studies and randomized, controlled interventions have shown that regular physical activity provides several health benefits. Alth ...
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Disparities in Women with Heart ...
Despite comprising over half of the heart failure population, women have been under-represented in most major clinical heart failure trials. Women w ...
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The Rise and Fall of Hypertensi ...
Hypertension is a progressive cardiovascular syndrome that arises from many differing, but interrelated, etiologies. Hypertension is the most preval ...
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Physical Activity, Weight Loss, ...
Contemporary studies now suggest that multifactorial risk factor modification—especially smoking cessation, more intensive dietary modifications, ph ...
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Valvular Heart Disease in Aging ...
Elderly women are at risk for aortic and mitral valve disease that may be challenging to manage because of co-morbidities. Many reports focus on the ...
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Clinical Utility of Multiple Bi ...
Current cardiovascular risk prediction is imprecise, with clinical treatment aimed at those with high risk of disease while neglecting those at inte ...
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