Effects of connexin-mimetic peptides on perfusion press ...
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Effects of connexin-mimetic pep ...
Background Gap junction intercellular communication plays a fundamental role in various tissues and organs. Gap junctions transfer ions and molecule ...
1.19 MB
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Effects of TJN-598, a new selec ...
Background Phosphodiesterase type IV (PDEIV) plays an important role in the immune response and inflammation. However, it is well known that classic ...
680.29 KB
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Involvement of bone-marrow-deri ...
Cellular mechanisms have been proposed in the pathogenesis of fibrotic processes in the kidney. In this setting, cell sources underlying the generat ...
423.69 KB
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Treatment of metastatic renal c ...
A better understanding of the molecular biology of renal cell carcinoma (RCC) and the emergence of molecular targeted drugs have revolutionized the ...
197.27 KB
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Regulation of WNK1 kinase by ex ...
Background Mutations of WNK kinase genes were identified as the cause of a hereditary hypertensive disease, pseudohypoaldosteronism type II; however ...
392.44 KB
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Clinicopathological insights in ...
Lupus nephritis comprises a spectrum of glomerular, vascular, and tubulointerstitial lesions, which has significant racial variation in severity and ...
455.73 KB
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Pathogenetic and therapeutic ap ...
IgA nephropathy is the most common primary chronic glomerulonephritis in the world and was first described by Berger et al. (J Urol Nephrol 74:694– ...
301.38 KB
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Pathogenesis and therapeutic im ...
Chronic kidney disease (CKD) is now widely accepted as a risk factor for cardiovascular disease and mortality. Heart failure patients with CKD have ...
375.94 KB
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Dickkopf-1 is frequently overex ...
Dickkopf-1 (DKK1) was known as a negative regulator of the Wnt signaling pathway, which played a crucial role in carcinogenesis. However, its functi ...
1.12 MB
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Molecular alterations as target ...
Treating metastatic osteosarcoma (OS) remains a challenge in oncology. Current treatment strategies target the primary tumour rather than metastases ...
241.87 KB
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Treatment outcome and prognosti ...
We retrospectively analyzed treatment outcomes and factors for poor prognosis for patients with renal cell cancer (RCC) bonemetastases. Patients wit ...
200.30 KB
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Alterations of the retinoblasto ...
Germline mutations affecting the retinoblastoma gene (RB1) predispose to inherited retinoblastomas but also other malignancies, including breast can ...
241.22 KB
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Fibroblast activation protein-a ...
Fibroblast activation protein-a (FAP) is a cell surface, serine protease of the post-prolyl peptidase family that is expressed in human breast cance ...
679.13 KB
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Impact of combined HDAC and mTO ...
The concept of molecular tumor targeting might provide new hope in the treatment of advanced prostate cancer. We evaluated metastasis blocking prope ...
571.82 KB
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c-Crk proto-oncogene contribute ...
As a member of adherens junction, p120-catenin (p120ctn) plays a major role in cell adhesions through stabilization of E-cadherin. p120ctn is transc ...
1.19 MB
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The synthetic triterpenoid CDDO ...
Survival following diagnosis of liver metastasis remains poor and improved treatment strategies to combat liver metastases are needed. Synthetic tri ...
532.05 KB
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Differential expression of FAK ...
The murine EL4 lymphoma cell line exists in variants that are either sensitive or resistant to phorbol 12-myristate 13-acetate (PMA). In sensitive c ...
724.53 KB
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Role of DDR1 in the gelatinases ...
Discoidin domain receptors (DDRs) are receptor tyrosine kinases that get activated by collagens in its native triple-helical form. In mammalian cell ...
590.35 KB
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Effect of zoledronic acid and a ...
Osteosarcoma (OSA) is an aggressive, highly metastatic and lytic primary bone neoplasm commonly affecting the appendicular skeleton of dogs and chil ...
957.42 KB
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IFN-c is essential for the inhi ...
We previously found that chronic alcohol consumption (20% w/v in drinking water) that models the level consumed by human alcoholics, when administer ...
دانلود 1
342.65 KB
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RGS22, a novel cancer/testis an ...
RGS22 is a novel testis specific gene. It is located within chromosome 8q22.2, which shows high relevance with tumor chromosomal aberrations. We in ...
1.01 MB
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Deletion of galectin-3 in the h ...
Galectin-3, a b galactoside–binding lectin, plays an important role in the processes relevant to tumorigenesis such as malignant cell transformation ...
598.27 KB
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Transient silencing of galectin ...
Pancreatic cancer demonstrates a strong resistance to anticancer drugs, presumably due to its resistance to drug induced apoptosis. Although gemcita ...
1,003.81 KB
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Is gastrointestinal dysfunction ...
Although impaired gastrointestinal motility from gastric cancer peritoneal metastasis (GCPM) causes extraordinary pain, its cause is unclear. Inters ...
936.83 KB
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Proteomic profiling of lipid ra ...
Tumor biomarkers assist in the early detection of cancer, act as therapeutic targets for intervention, and function as diagnostic indicators for the ...
984.97 KB
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