Alpha- and beta-adrenergic receptor (AR) protein expres ...
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Alpha- and beta-adrenergic rece ...
Breast cancer mortality is frequently associated with metastatic disease. Metastasis models have shown adrenoceptor (AR) stimulation induces cell mi ...
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Influence of stromal–epithelial ...
Stromal cell-secreted chemokines including CCL2 have been implicated in the primary tumor microenvironment, as mediators of tumor cell migration, pr ...
681.47 KB
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SWOG S0215: a phase II study of ...
SWOG trial S0102 showed significant activity of the combination of docetaxel and vinorelbine in HER2- negative metastatic breast cancer (MBC). For H ...
249.29 KB
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The effect of mTOR inhibition a ...
mTOR inhibitor rapamycin and its analogs are lipophilic, demonstrate blood–brain barrier penetration, and have shown promising antitumor effects in ...
880.33 KB
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LDH-A silencing suppresses brea ...
LDH-A, as the critical enzyme accounting for the transformation from pyruvate into lactate, has been demonstrated to be highly expressed in various ...
731.31 KB
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A signature of immune function ...
The clinical significance of tumor-infiltrating immune cells has been reported in a variety of human carcinomas including breast cancer. However, mo ...
915.01 KB
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The effect of system-level acce ...
Treatment decisions associated with ductal carcinoma in situ (DCIS), including the decision to undergo breast reconstruction, may be more problemati ...
293.99 KB
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Second primary breast, endometr ...
Breast cancer incidence increases with age and exhibits a Black-to-White crossover around age 45. Breast cancer survivors are at a significantly ele ...
261.91 KB
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Detection of aberrant promoter ...
Aberrant promoter methylation of genes is a common molecular event in breast cancer. Thus, DNA methylation analysis is expected to be a new tool for ...
553.25 KB
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Detection of aberrant promoter ...
Aberrant promoter methylation of genes is a common molecular event in breast cancer. Thus, DNA methylation analysis is expected to be a new tool for ...
306.05 KB
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Estrogen receptor-a and sex ste ...
Toll-like receptor 9 (TLR9) is a cellular DNAreceptor, which is widely expressed in cancer. Synthetic TLR9-ligands induce cancer cell invasion in vi ...
570.01 KB
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The peptide-hormone glucagon-li ...
The incretin hormone glucagon-like peptide (GLP)-1 is secreted from intestinal L cells in response to food intake, and promotes insulin secretion an ...
714.23 KB
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Risk factors by molecular subty ...
Differences in incidence, prognosis, and treatment response suggest gene expression patterns may discern breast cancer subtypes with unique risk fac ...
226.35 KB
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Oxidative stress and hematologi ...
Several adverse effects of chemotherapy treatments have been described, and most of these effects are associated with direct interactions between bl ...
450.36 KB
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Prognostic significance of gene ...
The association between promoter methylation status and survival was investigated in a large cohort of women with breast cancer, participants in the ...
284.80 KB
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The anatomy of fluid-yielding d ...
The concept of an intraductal approach to evaluate the breast microenvironment assumes direct access to the cancer-containing duct. Central duct acc ...
1,005.29 KB
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Correlation between docetaxel-i ...
Steroids and H2 blockers are commonly used as supportive care for taxane-containing chemotherapy, but they also affect docetaxel’s primary metaboliz ...
236.79 KB
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Assessing the RNA effect of 26 ...
Comprehensive genetic testing of the breast cancer susceptibility genes BRCA1 and BRCA2 identified approximately 16% of variants of unknown signific ...
847.50 KB
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A gene transcription signature ...
Obesity is thought to contribute to worse disease outcome in breast cancer as a result of increased levels of adipocyte-secreted endocrine factors, ...
703.37 KB
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Risk factors for lymphedema in ...
Risk factors for lymphedema and related arm symptoms in breast cancer (BC) survivors have not been examined using a large prospective population-bas ...
214.97 KB
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Gene expression profiling of br ...
Microtubule-targeting agents, including taxanes (Tax) and ixabepilone (Ixa), are important components of modern breast cancer chemotherapy regimens, ...
649.62 KB
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IL-15 and IL-2 increase Cetuxim ...
Triple negative breast cancer (TNBC) patients are not likely to benefit from anti-estrogen or anti-HER2 therapy and this phenotype is associated wit ...
656.49 KB
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Enhancement of chemotherapeutic ...
A subset of primary breast cancers and breast cancer cell lines express a hypermethylation defect (characterized by DNMT hyperactivity and DNMT3b ov ...
639.94 KB
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Breast cancer and spider telang ...
Angiogenesis is one of the hallmarks of breast cancer. The status of angiogenesis is important in therapy choice. Spider telangiectasias (telangiect ...
281.75 KB
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miRNA-34a is associated with do ...
Docetaxel is a chemotherapy drug to treat breast cancer, however as with many chemotherapeutic drugs resistance to docetaxel occurs in 50% of patien ...
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