Pathogenetic and therapeutic approaches to IgA nephropa ...
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Pathogenetic and therapeutic ap ...
IgA nephropathy is the most common primary chronic glomerulonephritis in the world and was first described by Berger et al. (J Urol Nephrol 74:694– ...
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Clinicopathological insights in ...
Lupus nephritis comprises a spectrum of glomerular, vascular, and tubulointerstitial lesions, which has significant racial variation in severity and ...
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Regulation of WNK1 kinase by ex ...
Background Mutations of WNK kinase genes were identified as the cause of a hereditary hypertensive disease, pseudohypoaldosteronism type II; however ...
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Treatment of metastatic renal c ...
A better understanding of the molecular biology of renal cell carcinoma (RCC) and the emergence of molecular targeted drugs have revolutionized the ...
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Involvement of bone-marrow-deri ...
Cellular mechanisms have been proposed in the pathogenesis of fibrotic processes in the kidney. In this setting, cell sources underlying the generat ...
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Effects of TJN-598, a new selec ...
Background Phosphodiesterase type IV (PDEIV) plays an important role in the immune response and inflammation. However, it is well known that classic ...
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Effects of connexin-mimetic pep ...
Background Gap junction intercellular communication plays a fundamental role in various tissues and organs. Gap junctions transfer ions and molecule ...
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Antigen-binding abilities of an ...
Background Nephrin is an essential protein for maintaining the normal structure of podocyte foot processes and the glomerular filtration barrier. To ...
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Growth factor Midkine is involv ...
Background Growth factor Midkine (MK), which expresses on endothelial cells and renal proximal tubules, has been implicated in inflammation-related ...
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Clinical significance of tubula ...
Background Acute kidney injury (AKI) is a common complication in critically ill patients. Urinary excretion of liver-type fatty acid-binding protein ...
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Renal preservation effect of ub ...
Background The aim of this study was to evaluate the renal preservation effect of ubiquinol, the reduced form of coenzyme Q10 (CoQ10). Methods Thre ...
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Upregulation of calbindin D28k ...
Background The calcium (Ca)-activated potassium (K) channel is an alternative K-secretory pathway in the apical membranes of the distal nephrons of ...
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Dual myeloperoxidase-antineutro ...
Background Both myeloperoxidase-associated antineutrophil cytoplasmic antibody (MPO-ANCA) and antiglomerular basement membrane antibody (anti-GBMAb) ...
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Glucocorticoid enhances hypoxia ...
Background Glucocorticoid (GC) treatment reportedly exaggerates renal fibrosis in progressive kidney diseases during which hypoxia occurs as an unav ...
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Cisplatin induces Sirt1 in asso ...
Background Sirt1, a mammalian homolog of silent information regulator 2 (Sir2), is the founding member of class III histone deacetylase (HDAC). Met ...
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The association between renal t ...
Background Injury to renal tubules plays an important role in the development of various renal diseases; however, the prevalence and significance of ...
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Steroids and azathioprine in th ...
Aim IgA nephropathy (IgAN) is a very common glomerulonephritis among young adults, but the best therapeutic approach has not been fully elucidated. ...
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Aldosterone-induced kidney inju ...
Background Aldosterone induces inflammation and fibrosis in the kidney, while nuclear factor jB (NFjB) plays key roles in inflammation mediated by v ...
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A simple model for predicting i ...
Background Human immunodeficiency virus (HIV)- infected individuals have concurrent risk factors for chronic kidney disease (CKD), but there are no ...
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Association between single nucl ...
Background Sirtuin is a member of the nicotinamide adenine dinucleotide (NAD)-dependent deacetylases, and has been reported to play a pivotal role i ...
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CD28 superagonist-induced regul ...
Background Naturally occurring regulatory T cells (Treg) are essential for the prevention of autoimmunity and overshooting immune responses to patho ...
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Management of anemia in chronic ...
Background Anemia is a factor that affects the outcome of patients with chronic kidney disease (CKD); however, there are only a few reports on the m ...
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Risk of macrovascular disease s ...
Background Although a high prevalence of macrovascular disease (MVD) has been reported in patients with stage 3 chronic kidney disease (CKD), few st ...
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Elevated serum levels of interl ...
Background Interleukin-18 (IL-18), a pro-inflammatory cytokine, is a predictor of cardiovascular and renal disease in diabetic patients. Postprandia ...
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Primed monocytes: putative culp ...
Background End-stage renal disease patients are known to be in a state of chronic low-grade inflammation and to have high infection-related morbidit ...
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