Ovarian Cancer Biomarkers: A Focus on Genomic and Prote ...
رایگان
Ovarian Cancer Biomarkers: A Fo ...
Among the gynaecological malignancies, ovarian cancer is one of the neoplastic forms with the poorest prognosis and with the bad overall and disease- ...
137.95 KB
رایگان
Pooled RNAi Screens - Technical ...
RNA interference (RNAi) screens have recently emerged as an exciting new tool for studying gene function in mammalian cells. In order to facilitate t ...
139.80 KB
رایگان
Microarray-Based Gene Expressio ...
Microarray studies have successfully shed light on various aspects of the molecular mechanisms behind the development of hepatocellular carcinoma (HC ...
142.48 KB
رایگان
The Fuzzy Logic of MicroRNA Reg ...
Genomic and clinical evidence suggest a major role of microRNAs (miRNAs) in the regulatory mechanisms of gene expression, with a clear impact on deve ...
145.52 KB
رایگان
The MDM2 Ubiquitination Signal ...
Genetic and biochemical studies have shown that Ser20 phosphorylation in the transactivation domain of p53 mediates p300-catalyzed DNA-dependent p53 ...
1.10 MB
رایگان
Multiple Functions of Rad9 for ...
DNA-damage checkpoints sense and respond to genomic damage. Human Rad9 (hRad9), an evolutionarily conserved gene with multiple functions for preservi ...
دانلود 1
145.86 KB
رایگان
Gβγ-Copurified Lipid Kinase Imp ...
G-protein .... dimers are prime regulators transmitting extracellular signals to wide-ranging cellular effectors including phosphoinositide 3-kinase ...
319.63 KB
رایگان
The Absence of Ser389 Phosphory ...
Phosphorylation is important in p53-mediated DNA damage responses. After UV irradiation, p53 is phosphorylated specifically at murine residue Ser389. ...
1.99 MB
رایگان
Ribosomal Proteins and Colorect ...
The ribosome is essential for protein synthesis. The composition and structure of ribosomes from several organisms have been determined, and it is we ...
152.25 KB
رایگان
The Role of the COG Database in ...
A major breakthrough in classifying proteins from different microbial genomes in terms of sequence similarity was the development of the COG concept ...
152.48 KB
رایگان
Role of Insulin and Growth Horm ...
Insulin/insulin-like growth factor-I (IGF-I) pathways are recognized as critical signaling pathways involved in the control of lifespans in lower org ...
48.03 KB
رایگان
Bcl2’s Flexible Loop Domain Reg ...
p53 not only functions as a transcription factor but also has a direct, apoptogenic role at the mitochondria. We have discovered that DNA damage-indu ...
965.77 KB
رایگان
The Human Pseudoautosomal Regio ...
The pseudoautosomal regions (PAR1 and PAR2) of the human X and Y chromosomes pair and recombine during meiosis. Thus genes in this region are not inh ...
167.88 KB
رایگان
Gene Expression Studies in Mult ...
Abstract: Multiple sclerosis (MS) is a serious neurological disorder affecting young Caucasian individuals, usually with an age of onset at 18 to 40 ...
168.61 KB
رایگان
Molecular Signature of HPV-Indu ...
The infection by mucosal human papillomavirus (HPV) is causally associated with tumor development in cervix and oropharynx. The mechanisms responsibl ...
170.05 KB
رایگان
Modifiers of Hearing Impairment ...
Lack of penetrance and variability of expression are common findings in nonsyndromic hearing loss with autosomal dominant mode of inheritance, but ar ...
176.11 KB
رایگان
Current Therapeutic Options for ...
Alzheimer’s disease (AD) is the most common neurodegenerative disease in the developed world. The increasing life expectancy in the last years has le ...
176.38 KB
رایگان
Recent Progress in Functional G ...
With the completion and near completion of many malaria parasite genome-sequencing projects, efforts are now being directed to a better understanding ...
181.56 KB
رایگان
Genetics Talks to Epigenetics? ...
Transcription is regulated by two major mechanisms. On the one hand, changes in DNA sequence are responsible for genetic gene regulation. On the othe ...
189.13 KB
رایگان
Computational Approaches for Pr ...
A central focus of cancer genetics is the study of mutations that are causally implicated in tumorigenesis. Although missense variants are commonly i ...
191.33 KB
رایگان
Feud or Friend? The Role of the ...
MicroRNAs (miRNAs) are short, noncoding, and single-stranded RNA molecules that negatively regulate gene expression. They are evolutionarily conserve ...
195.22 KB
رایگان
Longevity Genomics Across Speci ...
Unbiased genome-wide studies of longevity in S. cerevisiae and C. elegans have led to the identification of more than one hundred genes that determin ...
196.40 KB
رایگان
Genomics of Fungal Disease Resi ...
Tomato (Solanum lycopersicum) is an important vegetable crop worldwide. Often times, its production is hindered by fungal diseases. Important fungal ...
290.98 KB
رایگان
Midkine is a NF-κB-inducible ge ...
Background: Midkine is a heparin-binding growth factor that is over-expressed in various human cancers and plays important roles in cell transformati ...
685.26 KB
رایگان
Using Free and Open-Source Bioc ...
Whole-genome array Comparative Genomics Hybridization (aCGH) can be used to scan chromosomes for deletions and amplifications. Because of the increas ...
203.54 KB
رایگان
