Do mtDNA Mutations Participate in the Pathogenesis of S ...
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Do mtDNA Mutations Participate ...
The pathogenesis of sporadic Parkinson’s disease (PD) remains enigmatic. Mitochondrial complex-I defects are known to occur in the substantia nigra ( ...
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Parallel Gene Expression Profil ...
DNA microarray technology has been a valuable tool to provide a global view of the changes in gene expression that characterize different types of B ...
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Gene Clusters, Molecular Evolut ...
Traditionally eukaryotic genes are considered independently expressed under the control of their promoters and cis-regulatory domains. However, recen ...
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The Decade of Vaccines: An Oppo ...
Despite remarkable improvement in global immunisation coverage during the past 30 years, progress has not been uniform. The reasons underlying sub-op ...
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Expressional Analysis and Role ...
Perception of stimuli and activation of a signaling cascade is an intrinsic characteristic feature of all living organisms. Till date, several signal ...
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Cautionary Tail: The Presence o ...
As part of structural investigations of components of the molecular motor, dynein, we prepared the light chain, Robl1_mouse, with and without an N-te ...
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Gene Expression Profiling and i ...
The availability of sequenced genomes of human and many experimental animals necessitated the development of new technologies and powerful computatio ...
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The Role of Androgen Receptor M ...
Prostate tumour growth is almost always dependent upon the androgen receptor pathway and hence therapies aimed at blocking this signalling axis are u ...
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Recent Computational Approaches ...
This paper reviews recent computational approaches to the understanding of gene regulation in eukaryotes. Cis-regulation of gene expression by the bi ...
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The Human Glioma-Associated Onc ...
Sonic hedgehog (Shh) signaling is critically important for embryogenesis and other cellular processes in which GLI transcription factors mediate the ...
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H2A.Z-Mediated Genome-Wide Chro ...
The characterization of the involvement of different histone post-translational modifications (PTMs) and histone variants in chromatin structure has ...
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Myostatin in the Pathophysiolog ...
Myostatin is an endogenous, negative regulator of muscle growth determining both muscle fiber number and size. The myostatin pathway is conserved acr ...
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Molecular Pathophysiology of Re ...
Renal tubular acidosis (RTA) is characterized by metabolic acidosis due to renal impaired acid excretion. Hyperchloremic acidosis with normal anion g ...
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The C Terminus of p53 Family Pr ...
The p53 tumor suppressor is the most commonly mutated gene in human cancers. The ability of p53 to induce cell cycle arrest, apoptosis, DNA repair, a ...
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Genetic and Environmental Facto ...
Complex neurodevelopmental disorders, such as schizophrenia, autism, attention deficit (hyperactivity) disorder, (manic) depressive illness and addic ...
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Designing the Optimal Vaccine: ...
Many vaccines existing today provide strong protection against a wide variety of infectious organisms, and these consist of either live attenuated or ...
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Megsin Gene: Its Genomic Analys ...
It is critical to uncover genes specifically expressed in individual cell types for further understanding of cell biology and pathology. In order to ...
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Zebrafish as a Model System to ...
Zebrafish (Danio rerio) is a bona fide vertebrate model system for understanding human diseases. It allows the transparent visualization of the effec ...
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Pas de deux: Natural Killer Rec ...
Major histocompatibility complex (MHC) class I and NK cell receptor gene regions are a paradigm of genomic plasticity as they reveal a considerable d ...
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Challenges and Solutions in Pro ...
The accelerated growth of proteomics data presents both opportunities and challenges. Large-scale proteomic profiling of biological samples such as c ...
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Mechanisms and Signals for the ...
In eukaryotes, the nuclear membrane provides a physical barrier to the passive diffusion of macromolecules from and into the cytoplasm. Nucleocytopla ...
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How Many Mutant p53 Molecules A ...
The tumor suppressor p53 is transcription factor composed of four identical subunits. The majority of the mutations in p53 are missense mutations tha ...
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Advances in Genetical Genomics ...
Natural variation provides a valuable resource to study the genetic regulation of quantitative traits. In quantitative trait locus (QTL) analyses thi ...
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Gain-of-Function Mutations of R ...
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors in human gastrointestinal tract. We first found that most GISTs expres ...
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Patterns of Insertion and Delet ...
Nucleotide insertions and deletions (indels) are responsible for gaps in the sequence alignments. Indel is one of the major sources of evolutionary c ...
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